Evidence map›Paper›PMID 30287268›Full record

ArticleContemporary clinical trials2018

The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.

Laura M Thornton, Melissa A Munn-Chernoff, Jessica H Baker, Anders Juréus, Richard Parker, Anjali K Henders, Janne T Larsen, Liselotte Petersen, Hunna J Watson, Zeynep Yilmaz and 36 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01916538 (Anorexia Nervosa Genetics Initiative), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01916538 completednot on this map

Anorexia Nervosa Genetics Initiative

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2013 to 2016Enrolled22,445ConditionsAnorexia Nervosa
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Hoarding Symptoms in Eating Disorders: An Observational Cross-Sectional Study.The International journal of eating disorders · 2025
    Observational
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Relationship Between Intensive Passive Data Signals and Patterns of Binge-Eating Behaviors: From a Dynamical-System Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2025
    Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Laura M ThorntonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Melissa A Munn-ChernoffUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jessica H BakerUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anders JuréusDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Richard ParkerQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Anjali K HendersThe University of Queensland, Brisbane, QLD 4072, Australia.
Janne T LarsenAarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark.
Liselotte PetersenAarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark.
Hunna J WatsonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
Zeynep YilmazUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Katherine M KirkQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Scott GordonQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Virpi M LeppäDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Felicity C MartinQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
David C WhitemanQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Catherine M OlsenQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Thomas M WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Bartholin Alle 6, 8000 Aarhus, Denmark; Mental Health Services, Institute for Biological Psychiatry, MHC Sct. Hans, Kristineberg 3, 2100 Copenhagen, Denmark; University of Copenhagen, Nørregade 10, DK-1165 Copenhagen, Denmark.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Walter KayeUniversity of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Andrew W BergenBiorealm Research, 6101 W Centinela Ave # 270, Culver City, CA 90230, USA; Oregon Research Institute, Eugene, OR 97403, USA.
Katherine A HalmiWeill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
Michael StroberUniversity of California at Los Angeles, Los Angeles, CA 90095, USA.
Allan S KaplanUniversity of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada.
D Blake WoodsideUniversity of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada; Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.
James MitchellNeuropsychiatric Research Institute, 120 8th Street South, Fargo, ND 58103, USA.
Craig L JohnsonEating Recovery Center, 7351 E. Lowry Blvd., Suite 200, Denver, CO 80230, USA.
Harry BrandtThe Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
Steven CrawfordThe Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
L John HorwoodChristchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Joseph M BodenChristchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
John F PearsonChristchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Laramie E DuncanStanford University, 450 Serra Mall, Stanford, CA 94305-2004, USA.
Jakob GroveAarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark.
Manuel MattheisenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Aarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden; University of Würzburg, Sanderring 2, 97070 Würzburg, Germany.
Jennifer JordanChristchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Martin A KennedyChristchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Andreas BirgegårdDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Claes NorringDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Box 45436, 104 31 Stockholm, Sweden.
Tracey D WadeFlinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia.
Grant W MontgomeryThe University of Queensland, Brisbane, QLD 4072, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden; Gothenburg University, Box 100, SE-405 30 Gothenburg, Sweden.
Preben Bo MortensenAarhus University, Norde Ringgade 1, 8000 Aarhus, Denmark; Mental Health Services, Institute for Biological Psychiatry, MHC Sct. Hans, Kristineberg 3, 2100 Copenhagen, Denmark; University of Copenhagen, Nørregade 10, DK-1165 Copenhagen, Denmark.
Patrick F SullivanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Cynthia M BulikUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden. Electronic address: cbulik@med.unc.edu.

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M
Genetic and Environmental Risk for Alcohol and Eating Disorders Across DevelopmentK01AA025113 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MUNN-CHERNOFF, MELISSA ANNE · 2017 to 2021
$773k
BIOMARKERS OF WEIGHT CHANGE IN ANOREXIA NERVOSAK01MH106675 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, JESSICA H · 2016 to 2019
$651k
Shared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620k
NIAAA NIH HHS K01 AA025113NIMH NIH HHS K01 MH106675NIMH NIH HHS K01 MH109782NIMH NIH HHS U01 MH109528NIMH NIH HHS U24 MH068457
6 · The paper itself

Abstract

backgroundGenetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research.

methodsANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H.

resultsBlood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable.

conclusionsOur multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

Indexed as

AdolescentAdultAgedAnorexia NervosaAustraliaCase-Control StudiesDenmarkFeeding and Eating DisordersFemaleHumansInternetMiddle AgedNew ZealandPatient SelectionReproducibility of ResultsSurveys and QuestionnairesAnorexia nervosaEating disordersGenome-wide associationPsychiatric geneticsPsychiatric genomics consortiumSocial media

Identifiers

PMID30287268
PMCPMC6338222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.