ArticleEBioMedicine2018
Resting state functional connectivity in patients with remitted psychotic depression: A multi-centre STOP-PD study.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- 5-HTBiological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features.Molecular psychiatry · 2023Trial
- Cognition and future depression: associations with risk in those with and without a history of depression.BMJ mental health · 2026Article
- Resting-state fMRI graph theory analysis for predicting selective serotonin reuptake inhibitors treatment response in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.Journal of affective disorders · 2023Article
- Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration.Schizophrenia bulletin · 2022Article
- Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Bipolar Disorder in Comparison to the Treatment of Unipolar Depression in a Naturalistic Setting.Brain sciences · 2022Article
- Structural brain networks in remitted psychotic depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Indexing the neurobiology of psychotic depression with resting state connectivity: Insights from the STOP-PD study.EBioMedicine · 2018Article
- Iranian Brain Imaging Database: A Neuropsychiatric Database of Healthy Brain.Basic and clinical neuroscienceArticle
- Examining the Dominant Presence of Brain Grey Matter in Autism During Functional Magnetic Resonance Imaging.Basic and clinical neuroscienceReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThere is paucity of neurobiological knowledge about major depressive disorder with psychotic features ("psychotic depression"). This study addresses this knowledge gap by using resting state functional magnetic resonance imaging (R-fMRI) to compare functional connectivity in patients with psychotic depression and healthy controls.
methodsWe scanned patients who participated in a randomized controlled trial as well as healthy controls. All patients achieved remission from depressive and psychotic symptoms with sertraline and olanzapine. We employed Independent Component Analysis in independent samples to isolate the default mode network (DMN) and compared patients and controls.
findingsThe Toronto sample included 28 patients (mean [SD], age 56·2 [13·7]) and 39 controls (age 55·1 [13·5]). The Replication sample included 29 patients (age 56·1 [17·7]) and 36 controls (age 48·3 [17·9]). Patients in the Toronto sample demonstrated decreased between-network functional connectivity between the DMN and bilateral insular, somatosensory/motor, and auditory cortices with peak activity in the right planum polare (t = 4·831; p = 0·001, Family Wise Error (FWE) corrected). A similar pattern of between-network functional connectivity was present in our Replication sample with peak activity in the right precentral gyrus (t = 4·144; p = 0·003, FWE corrected).
interpretationRemission from psychotic depression is consistently associated with an absence of increased DMN-related functional connectivity and presence of decreased between-network functional connectivity. Future research will evaluate this abnormal DMN-related functional connectivity as a potential biomarker for treatment trajectories.
fundingNational Institute of Mental Health.
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