ArticleMicrobiome2018
Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas.
Article in Microbiome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- Dysbiosis of the nasal microbiome is associated with prospective acute exacerbation of COPD.Microbiome · 2026Article
- New insights into mesenchymal stem cells in inflammatory subtypes of asthma.Frontiers in immunology · 2025Review
- Airway Microbiota Profiles in Children With and Without Asthma: A Comparative Study.Journal of asthma and allergy · 2025Article
- Role of the Gut-Lung Microbiome Axis in Airway Inflammation in OVA-Challenged Mice and the Effect of Azithromycin.Journal of inflammation research · 2025Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Characterization of the oral mycobiome of Portuguese with allergic rhinitis and asthma.Current research in microbial sciences · 2024Article
- The nasal mycobiome of individuals with allergic rhinitis and asthma differs from that of healthy controls in composition, structure and function.Frontiers in microbiology · 2024Article
- Oral Microbiota and Pediatric Asthma Phenotype: A New Window for Biomarkers?American journal of respiratory and critical care medicine · 2023Article
- The microbial composition of larval airways from Drosophila melanogaster differ between specimens from laboratory and natural habitats.Environmental microbiome · 2023Article
- Bacterial Microbiota of Asthmatic Children and Preschool Wheezers' Airways-What Do We Know?Microorganisms · 2023Review
- Paediatric Asthma and the Microbiome: A Systematic Review.Microorganisms · 2023Review
- A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions.Microorganisms · 2023Article
- Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma.Nutrients · 2023Review
- The oral bacteriomes of patients with allergic rhinitis and asthma differ from that of healthy controls.Frontiers in microbiology · 2023Article
- Human airway and lung microbiome at the crossroad of health and disease (Review).Experimental and therapeutic medicine · 2023Review
- Environmental factors related to differences in the microbiota in the upper respiratory tract in young children: Focusing on the impact of early nursery attendance.Frontiers in pediatrics · 2023Article
- A pilot study exploring the association of bronchial bacterial microbiota and recurrent wheezing in infants with atopy.Frontiers in cellular and infection microbiology · 2023Article
- Characterization of the upper respiratory tract microbiota in Chilean asthmatic children reveals compositional, functional, and structural differences.Frontiers in allergy · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPediatric asthma is the most common chronic childhood disease in the USA, currently affecting ~ 7 million children. This heterogeneous syndrome is thought to encompass various disease phenotypes of clinically observable characteristics, which can be statistically identified by applying clustering approaches to patient clinical information. Extensive evidence has shown that the airway microbiome impacts both clinical heterogeneity and pathogenesis in pediatric asthma. Yet, so far, airway microbiotas have been consistently neglected in the study of asthma phenotypes. Here, we couple extensive clinical information with 16S rRNA high-throughput sequencing to characterize the microbiota of the nasal cavity in 163 children and adolescents clustered into different asthma phenotypes.
resultsOur clustering analyses identified three statistically distinct phenotypes of pediatric asthma. Four core OTUs of the pathogenic genera Moraxella, Staphylococcus, Streptococcus, and Haemophilus were present in at least 95% of the studied nasal microbiotas. Phyla (Proteobacteria, Actinobacteria, and Bacteroidetes) and genera (Moraxella, Corynebacterium, Dolosigranulum, and Prevotella) abundances, community composition, and structure varied significantly (0.05 < P ≤ 0.0001) across asthma phenotypes and one of the clinical variables (preterm birth). Similarly, microbial networks of co-occurrence of bacterial genera revealed different bacterial associations across asthma phenotypes.
conclusionsThis study shows that children and adolescents with different clinical characteristics of asthma also show different nasal bacterial profiles, which is indicative of different phenotypes of the disease. Our work also shows how clinical and microbial information could be integrated to validate and refine asthma classification systems and develop biomarkers of disease.
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