Evidence map›Paper›PMID 30286773›Full record

ArticleGenome biology2018

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions.

Yanli Wang, Fan Song, Bo Zhang, Lijun Zhang, Jie Xu, Da Kuang, Daofeng Li, Mayank N K Choudhary, Yun Li, Ming Hu and 3 more

Abstract read
In one paragraph

Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 374 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
374citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

374 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. rs57494551 increases CXCR5 expression and IgMJournal of gastroenterology · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

314 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yanli WangBioinformatics and Genomics Program, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Fan SongBioinformatics and Genomics Program, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Bo ZhangBioinformatics and Genomics Program, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Lijun ZhangDepartment of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State Hershey, Hershey, PA, 17033, USA.
Jie XuDepartment of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State Hershey, Hershey, PA, 17033, USA.
Da KuangDepartment of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Daofeng LiDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, 63108, USA.
Mayank N K ChoudharyDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, 63108, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Ming HuDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Ross HardisonCenter for Computational Biology and Bioinformatics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Ting WangDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, 63108, USA. twang@genetics.wustl.edu.
Feng YueBioinformatics and Genomics Program, The Pennsylvania State University, University Park, State College, PA, 16802, USA. fyue@hmc.psu.edu.ORCID 0000-0002-7954-5462

Funding

San Diego Center for 4D Nucleome ResearchU54DK107977 · NIDDK · LUDWIG INSTITUTE FOR CANCER RES LTD · PI MURRE, CORNELIS, REN, BING · 2015 to 2019
$9.4M
VISION: ValIdated Systematic IntegratiON of epigenomic dataR24DK106766 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLOBEL, GERD A, BODINE, DAVID M. · 2016 to 2020
$6.2M
THE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2M
RESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICSR25DA027995 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN, RICE, JOHN P. · 2009 to 2019
$4.3M
Impact of genetic variants on gene regulation and 3D genome organization in human diseasesR35GM124820 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Feng Yue · 2017 to 2026
$4.0M
DECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7M
Genetic Studies of Blood Cell Traits in Multi-Ethnic CohortsR01HL129132 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN, REINER, ALEXANDER P · 2016 to 2019
$2.7M
Connecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4M
Visualization, modeling and validation of chromatin interaction dataR01HG009906 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YUE, FENG · 2018 to 2022
$2.0M
The WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9M
Design and Analysis of Sequencing-based Studies for Complex Human TraitsR01HG006292 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2011 to 2015
$1.8M
ADVANCED EPI/GENOME BROWSER WITH ENHANCED VISUALIZATION AND ANALYSIS TOOLSR01HG007354 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2013 to 2016
$1.5M
NCI NIH HHS U01 CA200060NHGRI NIH HHS R01 HG006292NHGRI NIH HHS R01 HG007175NHGRI NIH HHS R01 HG007354NHGRI NIH HHS R01 HG009906NHGRI NIH HHS U01 HG009391NHLBI NIH HHS R01 HL129132NIDDK NIH HHS U54 DK107977NIEHS NIH HHS R01 ES024992NIEHS NIH HHS U24 ES026699NIGMS NIH HHS R35 GM124820NIH HHS 1U01CA200060NIH HHS R01ES024992NIH HHS R01HG006292NIH HHS R01HG007175NIH HHS R01HG007354NIH HHS R01HL129132NIH HHS R35GM124820NIH HHS U01HG009391NIH HHS U24ES026699NIH HHS U54DK107977
6 · The paper itself

Abstract

Here, we introduce the 3D Genome Browser, http://3dgenome.org , which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types. We design a new binary data format for Hi-C data that reduces the file size by at least a magnitude and allows users to visualize chromatin interactions over millions of base pairs within seconds. Our browser provides multiple methods linking distal cis-regulatory elements with their potential target genes. Users can seamlessly integrate thousands of other omics data to gain a comprehensive view of both regulatory landscape and 3D genome structure.

Indexed as

Genome, HumanImaging, Three-DimensionalWeb BrowserAnimalsChromatinDatabases, GeneticDeoxyribonuclease IDNA, IntergenicGenetic VariationHumansMiceNeoplasmsPolymorphism, Single NucleotideSpecies SpecificityChromatinDeoxyribonuclease IDNA, Intergenic

Identifiers

PMID30286773
PMCPMC6172833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.