Evidence map›Paper›PMID 30286720›Full record

ArticleBMC medical research methodology2018

A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy.

Paul M Bakaki, Jennifer Staley, Rujia Liu, Neal Dawson, Negar Golchin, Alexis Horace, Hannah Johnson, Jennifer Waldron, Almut Winterstein, Lawrence C Kleinman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical research methodology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul M BakakiDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA. pmb18@case.edu.ORCID 0000-0002-3482-2884
Jennifer StaleyRainbow Babies and Children's Hospital, University Hospitals, Cleveland, OH, USA.
Rujia LiuDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Neal DawsonDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Negar GolchinSchool of Pharmacy, University of Washington, Seattle, WA, USA.
Alexis HoraceDepartment of Clinical Sciences, University of Louisiana at Monroe College of Pharmacy, Monroe, LA, USA.
Hannah JohnsonDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Jennifer WaldronRainbow Babies and Children's Hospital, University Hospitals, Cleveland, OH, USA.
Almut WintersteinCollege of Pharmacy, University of Florida, Gainesville, FL, USA.
Lawrence C KleinmanRainbow Babies and Children's Hospital, University Hospitals, Cleveland, OH, USA.
Shari D BolenDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
NCATS NIH HHS KL2 TR000440
6 · The paper itself

Abstract

backgroundPolypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this manuscript, we report our transdisciplinary scoping review methodology.

methodsAfter establishing a transdisciplinary team, we iteratively developed standard operating procedures for the study's search strategy, inclusion/exclusion criteria, screening, and data extraction. We searched eight bibliographic databases, screened abstracts and full text articles, and extracted data from included studies using standardized forms. We held regular team meetings and performed ongoing internal validity measurements to maintain consistent and quality outputs.

resultsWith the aid of EPPI Reviewer collaborative software, our transdisciplinary team of nine members performed dual reviews of 363 included studies after dual screening of 4398 abstracts and 1082 full text articles. We achieved overall agreement of 85% and a kappa coefficient of 0.71 (95% CI 0.68-0.74) while screening full text articles. The screening and review processes required about seven hours per extracted study. The two pharmacists, an epidemiologist, a neurologist, and a librarian on the review team provided internal consultation in these key disciplines. A stakeholder group of 10 members with expertise in evidence synthesis, research implementation, pediatrics, mental health, epilepsy, pharmacoepidemiology, and pharmaceutical outcomes were periodically consulted to further characterize pediatric polypharmacy.

conclusionsA transdisciplinary approach to scoping reviews, including internal and external consultation, should be considered when addressing complex cross-disciplinary questions.

Indexed as

Cooperative BehaviorPolypharmacyChildDatabases, BibliographicDelivery of Health CareHumansInterdisciplinary CommunicationPatient Care TeamPediatricsScoping Reviews as TopicCollaborative researchPediatric polypharmacyScoping reviewTeam scienceTransdisciplinary research

Identifiers

PMID30286720
PMCPMC6172739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.