ArticleAnnals of pediatric endocrinology & metabolism2018
Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes.
Article in Annals of pediatric endocrinology & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05892848 (Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between type 1 diabetes mellitus and reduced bone mineral density in children: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Bone mineral density in children and adolescents with type 1 diabetes: A case-control study from South India.Journal of family medicine and primary care · 2026Article
- Childhood type 1 diabetes is associated with abnormal bone development.Pediatric diabetes · 2022Article
- Gut Microbiota in Bone Health and Diabetes.Current osteoporosis reports · 2021Review
- Bone Mineral Density across the Lifespan in Patients with Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- The association of extreme body weight with bone mineral density in Saudi children.Annals of African medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMany studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD.
methodsPrepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI).
resultsThe mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8-11.3 years). Initial mean glycosylated hemoglobin (HbA1c) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA1c. Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023).
conclusionPrepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.
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