Evidence map›Paper›PMID 30286242›Full record

ArticleJournal of speech, language, and hearing research : JSLHR2018

Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.

Nicholas S Reed, Jennifer A Deal, Matthew G Huddle, Joshua F Betz, Bethany E Bailey, Elyse J McGlumphy, Allen O Eghrari, S Amer Riazuddin, Frank R Lin, John D Gottsch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of speech, language, and hearing research : JSLHR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas S ReedDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
Jennifer A DealCenter on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD.
Matthew G HuddleDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
Joshua F BetzCenter on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD.
Bethany E BaileyThe Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.
Elyse J McGlumphyThe Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.
Allen O EghrariThe Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.
S Amer RiazuddinThe Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.
Frank R LinDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
John D GottschThe Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD.

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Genetics of Fuchs Corneal DystrophyR01EY016835 · NEI · JOHNS HOPKINS UNIVERSITY · PI GOTTSCH, JOHN D · 2007 to 2017
$5.7M
Role and Mechanism of Hearing Impairment in Cognitive Decline and DementiaK01AG054693 · NIA · JOHNS HOPKINS UNIVERSITY · PI DEAL, JENNIFER ANNE · 2017 to 2022
$773k
NCATS NIH HHS KL2 TR001077NEI NIH HHS R01 EY016835NIA NIH HHS K01 AG054693
6 · The paper itself

Abstract

Purpose: Although Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown. Method: This is a case-control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10). Generalized estimating equations were used to compare mean better-hearing ear thresholds in the 2 groups adjusted for age, sex, race, and noise exposure. Results: Patients with FCD had higher hearing thresholds (worse hearing) in lower frequencies (mean difference at 0.5 kHz = 3.49 dB HL) and lower hearing thresholds (better hearing) in higher frequencies (difference at 4 kHz = -4.25 dB HL) compared with population-based controls. Conclusion: In the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship.

Indexed as

AgedAudiometry, Pure-ToneAuditory ThresholdCase-Control StudiesFemaleFuchs' Endothelial DystrophyHearing LossHumansMalePilot Projects

Identifiers

PMID30286242
PMCPMC6428237

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.