ArticlePLoS neglected tropical diseases2018
Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury.PLoS neglected tropical diseases · 2026Article
- Venom variation and the future of antivenom design: Integrating population venomics, evolutionary toxinology, and precision therapeutics.Toxicon: X · 2026Review
- Article
- Being Stung Once or Twice by Bees (International journal of molecular sciences · 2024Article
- Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies.Communications biology · 2024Review
- Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming.Toxicon: X · 2023Article
- Design of an Anti-HMGB1 Synthetic Antibody forJournal of the American Chemical Society · 2023Article
- Unveiling the functional epitopes of cobra venom cytotoxin by immunoinformatics and epitope-omic analyses.Scientific reports · 2023Article
- Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction.Polymers · 2022Review
- Synthetic hydrogel nanoparticles for sepsis therapy.Nature communications · 2021Article
- Review
- Synthesis of a High Affinity Complementary Peptide-Polymer Nanoparticle (NP) Pair Using Phage Display.ACS applied bio materials · 2021Article
- Evolution Bites - Timeworn Inefficacious Snakebite Therapy in the Era of Recombinant Vaccines.Indian pediatrics · 2021Review
- The Influence of Silver Nanoparticles Against Toxic Effects ofInternational journal of nanomedicine · 2021Article
- Green synthesis of silver nanoparticles using Indian male fern (Toxicology research · 2020Article
- Article
- Pathogenesis of local necrosis induced by Naja atra venom: Assessment of the neutralization ability of Taiwanese freeze-dried neurotoxic antivenom in animal models.PLoS neglected tropical diseases · 2020Article
- Hybrid hydrogels for biomedical applications.Current opinion in chemical engineering · 2019Article
- Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.PLoS neglected tropical diseases · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective in the control of local tissue damage. A novel approach to mitigate the progression of local tissue damage that could complement the antivenom therapy of envenomings is proposed. We describe an abiotic hydrogel nanoparticle engineered to bind to and modulate the activity of a diverse array of PLA2 and 3FTX isoforms found in Elapidae snake venoms. These two families of protein toxins share features that are associated with their common (membrane) targets, allowing for nanoparticle sequestration by a mechanism that differs from immunological (epitope) selection. The nanoparticles are non-toxic in mice and inhibit dose-dependently the dermonecrotic activity of Naja nigricollis venom.
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