ArticleRadiation oncology (London, England)2018
A retrospective dosimetry study of intensity-modulated radiotherapy for nasopharyngeal carcinoma: radiation-induced brainstem injury and dose-volume analysis.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.The Cochrane database of systematic reviews · 2025Pooled it
- Ensemble RBE Modeling in Proton Therapy: A Meta-Synthesis Framework for Dose Assessment in the Brainstem and Spinal Cord.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Periventricular radionecrosis after conventionally fractionated radiation for low grade meningiomas.Radiation oncology (London, England) · 2025Article
- Individualized treatment of nasopharyngeal carcinoma with lung metastasis in an elderly patient: A case report.Oncology letters · 2025Article
- Radiation Dose-Induced Carotid Artery Stenosis and Brain Necrosis in Head and Neck Cancer-A Real World Cohort Study.Cancers · 2024Article
- Brain Stem Glioma Recurrence: Exploring the Therapeutic Frontiers.Journal of personalized medicine · 2024Review
- Specific-CT brain template construction and retrospective dosimetric comparison study in brain for nasopharyngeal carcinoma patients treated with IMRT or VMAT.American journal of cancer research · 2024Article
- Understanding the Radiation Dose Variability in Nasopharyngeal Cancer: An Organs-at-Risk Approach.Cureus · 2023Article
- A detailed dosimetric comparative study of IMRT and VMAT in normal brain tissues for nasopharyngeal carcinoma patients treated with radiotherapy.Frontiers in radiology · 2023Article
- Distribution pattern of medial group retropharyngeal lymph nodes and its implication in optimizing clinical target volume in nasopharyngeal carcinoma.Frontiers in oncology · 2023Article
- Organs-at-risk dose constraints in head and neck intensity-modulated radiation therapy using a dataset from a multi-institutional clinical trial (JCOG1015A1).Radiation oncology (London, England) · 2022Article
- Dosimetric analysis of radiation-induced brainstem necrosis for nasopharyngeal carcinoma treated with IMRT.BMC cancer · 2022Article
- Research progress on mechanism and dosimetry of brainstem injury induced by intensity-modulated radiotherapy, proton therapy, and heavy ion radiotherapy.European radiology · 2020Review
- Superiority of intensity-modulated radiation therapy in nasopharyngeal carcinoma with skull-base invasion.Journal of cancer research and clinical oncology · 2020Article
- Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review.BMC musculoskeletal disorders · 2020Review
- Head and Neck Radiation Therapy Patterns of Practice Variability Identified as a Challenge to Real-World Big Data: Results From the Learning from Analysis of Multicentre Big Data Aggregation (LAMBDA) Consortium.Advances in radiation oncologyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRadiation therapy is the standard radical treatment for nasopharyngeal carcinoma (NPC) but also causes transient as well as long-term complications. Patients who develop severe radiation-induced brainstem injuries have a poor prognosis due to the lack of effective medical therapies. However, the relationship between brainstem injury and radiation volume dose is unknown. In this study, we found that radiation-induced brainstem injury was significantly associated with brainstem dose per unit volume.
methodsA retrospective analysis was performed on a consecutive cohort of 327 patients with NPC receiving IMRT from May 2005 to December 2014. Dose-volume data and long-term outcome were analyzed.
resultsThe median follow-up duration was 56 months (range, 3-141 months), and six with T
conclusionsRadiotherapy-induced brainstem injury was uncommon in patients with NPC who received definitive IMRT. Multiple dose-volume data may be the dose tolerance of radiation-induced brainstem injury.
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