Evidence map›Paper›PMID 30285704›Full record

ArticleBMC complementary and alternative medicine2018

A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats.

Sihle Ephraim Mabhida, Rabia Johnson, Musawenkosi Ndlovu, Nonhlakanipho Felicia Sangweni, Johan Louw, Andrew Opoku, Rebamang Anthony Mosa

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sihle Ephraim MabhidaDepartment of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa. sihlemabhida@gmail.com.
Rabia JohnsonBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, 7505, South Africa.
Musawenkosi NdlovuDepartment of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa.
Nonhlakanipho Felicia SangweniDepartment of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa.
Johan LouwBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, 7505, South Africa.
Andrew OpokuDepartment of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa.
Rebamang Anthony MosaDepartment of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa.
University of Zululand · ZASouth African Medical Research Council · ZA

Funding

National Research Foundation-112401 112401National Treasury under the South African Medical Research Councils' Research Strengthening and Capacity Development Funding Opportunity for Selected Universities Initiative PC 57009University of zululand UZRC
6 · The paper itself

Abstract

backgroundA substantial literature supports antidiabetic properties of the lanosteryl triterpene (methyl-3β-hydroxylanosta-9,24-dien-21-oate, RA-3) isolated from Protorhus longifolia stem bark. However, the molecular mechanism(s) associated with the antihyperglycemic properties of the triterpene remained to be explored. The current study aimed at investigating the molecular mechanism(s) through which RA-3 improves insulin signaling in streptozotocin-induced type 1 diabetic rats.

methodsThe type 1 diabetic rats were treated daily with a single oral dose of RA-3 (100 mg/kg) for 28 days. The rats were then sacrificed, and blood, skeletal muscle and pancreases were collected for biochemical, protein expression and histological analysis, respectively.

resultsPersistently high blood glucose levels in the diabetic control rats significantly increased expression of IRS-1

conclusionsIt is apparent that RA-3 is able to improve the insulin signaling in type 1 diabetic rats. Its beta (β)-cells protecting mechanism could be attributed to its ability to alleviate inflammation and oxidative stress in the cells.

Indexed as

AnacardiaceaeAnimalsBlood GlucoseCatalaseDiabetes Mellitus, Type 1Glucose Transporter Type 4GlutathioneGlycogen Synthase Kinase 3 betaHumansHypoglycemic AgentsInsulinLanosterolMaleOxidative StressPlant BarkPlant ExtractsBlood GlucoseCatalaseGlucose Transporter Type 4GlutathioneGlycogen Synthase Kinase 3 betaHypoglycemic AgentsInsulinLanosterolmethyl 3-hydroxylanosta-9,24-dien-21-oatePlant ExtractsSuperoxide DismutaseGlucose transporter 4HyperglycemiaOxidative stressType 1 diabetes and lanosteryl triterpene

Identifiers

PMID30285704
PMCPMC6167861
OpenAlexW2894835494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.