ArticleBMC gastroenterology2018
A comparison of pyogenic liver abscess in patients with or without diabetes: a retrospective study of 246 cases.
Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 67 citations in OpenAlex.
- When Clinical Improvement Does Not Reflect Radiological Response: A Culture-Negative Giant Pyogenic Liver Abscess.Healthcare (Basel, Switzerland) · 2026Article
- Sodium-glucose cotransporter-2 inhibitors and the risk for liver abscess in patients with type 2 diabetes mellitus: a nationwide retrospective cohort study.Scientific reports · 2026Article
- Clinical Relevance and Utility of Serum APOC2 Levels in Patients with Type 2 Diabetes Mellitus: A Comparative Study on Subjects with and without Pyogenic Liver Abscess.Hepatic medicine : evidence and research · 2026Article
- Pyogenic liver abscess in the North Denmark Region - a population-based cohort study (2010-2022).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Comparison of Clinical Features and Treatment Outcomes of Pyogenic Liver Abscess in Diabetic and Non-Diabetic Patients in a Chinese Hospital.Infection and drug resistance · 2026Article
- Clinical predictors of multidrug-resistant Gram-negative pyogenic liver abscess and nomogram construction: A retrospective analysis.World journal of gastroenterology · 2025Article
- Lactate promotes invasive Klebsiella pneumoniae liver abscess syndrome by increasing capsular polysaccharide biosynthesis via the PTS-CRP axis.Nature communications · 2025Article
- Predictive factors for liver abscess liquefaction degree based on clinical, laboratory, and computed tomography data.World journal of gastrointestinal surgery · 2025Article
- The microbiological features and risk factors for liver abscess after thermal ablation of liver cancer.Frontiers in cellular and infection microbiology · 2025Article
- Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae.BMC gastroenterology · 2024Article
- Article
- Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis.World journal of emergency medicine · 2024Article
- Article
- Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus.Infection and drug resistance · 2024Article
- Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess.Scientific reports · 2023Article
- Clinical manifestations, diagnosis, treatment, and outcome of pyogenic liver abscess: a retrospective study.The Journal of international medical research · 2023Article
- Machine learning models for prediction of invasion Klebsiella pneumoniae liver abscess syndrome in diabetes mellitus: a singled centered retrospective study.BMC infectious diseases · 2023Article
- Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population.Infection and drug resistance · 2023Article
- Changes in clinical and CT manifestations related to liver abscesses in patients with vs. without basic diabetes mellitus before and after CT-guided interventional therapy: An observational study.Clinics (Sao Paulo, Brazil) · 2023Observational
- Evaluation of the Diagnostic Performance of mNGS in Detecting Intra-Abdominal Infections of the Emergency Department Patients.Infection and drug resistance · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundPyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to identify these differences, summarize the clinical experience, and improve the diagnosis and treatment of PLA.
methodsThe patients were enrolled in a teaching hospital from January 2012 to December 2016. The patients were separated into two groups based on comorbidity with diabetes mellitus (DM). The DM group was further separated into two subgroups according to the HbA1C concentration to investigate whether glycaemic control affected the clinical characteristics of PLA patients with DM. Chi-square, Fisher's exact test, and t-tests were used to analyse and evaluate differences between the two groups.
resultsTwo hundred and forty-six PLA patients were identified and 90 (36.6%) had comorbid DM. Patients with DM were older, had higher levels of alkaline phosphatase and γ-glutamyl transferase, hypertension, a loss of body weight, a single abscess, and combined antibiotic therapy with the use of carbapenems and Klebsiella pneumoniae in their blood cultures but a less frequent history of abdominal surgery and Escherichia coli in their pus cultures. When DM patients were compared to non-DM patients, each of these differences was significant (P < 0.05). Diabetic PLA patients with poor glycaemic control had a significantly higher proportion of fever and both lobes abscess(P < 0.05).
conclusionPLA patients with diabetes are older, have more serious complications, a higher prevalence of cardiovascular disease, an increased use of combined antibiotic therapy with carbapenem, and K. pneumoniae as the predominant pathogen, but these patients had fewer abdominal surgeries and fewer E. coli infections. In addition, poorly controlled glycaemia in diabetic PLA patients is associated with high incidence of fever and both lobes abscess.
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