ArticleThe Journal of physiology2019
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Gender Differences in the Context of Obstructive Sleep Apnea and Metabolic Diseases.Frontiers in physiology · 2021Pooled it
- GLP-1 Receptor Agonists in Obstructive Sleep Apnea: A Translational Perspective on Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice.bioRxiv : the preprint server for biology · 2026Article
- Ageing reveals the latent effects of early life stress on respiratory and metabolic function in female rats: Novel insights into the sex-specific origins of sleep apnoea.Experimental physiology · 2026Article
- Diet-induced obesity in mice increases carotid body chemosensitivity via the leptin-TRPM7 pathway.The Journal of physiology · 2025Article
- Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders.The Journal of physiology · 2025Review
- Leptin receptor downregulation in the carotid body treats obesity-induced hypertension.Journal of neurophysiology · 2025Article
- Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- Carotid body denervation improves hyperglycemia in obese mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Obstructive Sleep Apnea Syndrome and Obesity Indicators, Circulating Blood Lipid Levels, and Adipokines Levels: A Bidirectional Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2024Article
- Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity.Cell reports · 2023Article
- On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?The Journal of physiology · 2023Article
- Maturational effect of leptin on COPediatric research · 2023Article
- Review
- Article
- Acute effects of insulin and insulin-induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs.Experimental physiology · 2023Article
- The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.Frontiers in physiology · 2023Article
- Chronic Metformin Administration Does Not Alter Carotid Sinus Nerve Activity in Control Rats.Advances in experimental medicine and biology · 2023Article
- Neurochemical Anatomy of the Mammalian Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.The Journal of physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 3 countries.
Funding
Abstract
key pointsLeptin is a potent respiratory stimulant. A long functional isoform of leptin receptor, LepR ABSTRACT: Leptin is a potent respiratory stimulant. The carotid bodies (CB) express the long functional isoform of leptin receptor, LepR
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.