Evidence map›Paper›PMID 30285266›Full record

ArticleSouthern medical journal2018

Protocol to Improve Genotyping of Non-Small-Cell Lung Cancer Diagnosed Using EBUS-TBNA.

Christina R Bellinger, Deepankar Sharma, Travis Dotson, Jimmy Ruiz, Graham Parks, Edward F Haponik

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Southern medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christina R BellingerFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
Deepankar SharmaFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
Travis DotsonFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
Jimmy RuizFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
Graham ParksFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
Edward F HaponikFrom the Wake Forest University School of Medicine, Winston-Salem, and the W.G. (Bill) Hefner Veterans Administration Medical Center, Salisbury, NC.
W. G. (Bill) Hefner VA Medical Center · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

objectivesTargeted therapies for non-small-cell lung cancers (NSCLCs) are based on the presence of driver mutations such as epidermal growth factor receptor (EGFR) and the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) translocation. Endobronchial ultrasound-guided-transbronchial needle aspiration (EBUS-TBNA) is a first-line modality for diagnosing and staging NSCLC. A quality improvement protocol maximizing tissue acquisition for molecular analysis has not been previously described.

methodsWe instituted a standardized protocol designed from a multidisciplinary meeting of the pulmonology, oncology, and pathology departments for the acquisition and on-site processing of samples obtained through EBUS-TBNA to improve the yield for genetic analysis of EGFR and ALK testing.

resultsPreprotocol there were 50 NSCLCs (29 adenocarcinomas) and postprotocol there were 109 NSCLCs (52 adenocarcinomas). A statistically significant increase in yield for molecular analysis was seen in both EGFR (36% preprotocol and 80% postprotocol,

conclusionsImplementation of a standardized protocol with EBUS-TBNA was associated with an increase in adequacy for molecular genetic analysis in NSCLC.

Indexed as

Endoscopic Ultrasound-Guided Fine Needle AspirationAgedAnaplastic Lymphoma KinaseCarcinoma, Non-Small-Cell LungCell Cycle ProteinsClinical ProtocolsErbB ReceptorsFemaleGenotypeHumansLung NeoplasmsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm StagingSerine EndopeptidasesALK protein, humanAnaplastic Lymphoma KinaseCell Cycle ProteinsEML4 protein, humanErbB ReceptorsMicrotubule-Associated ProteinsSerine Endopeptidases

Identifiers

PMID30285266
PMCPMC6778407
OpenAlexW2895259618

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.