Evidence map›Paper›PMID 30285231›Full record

ArticleSocial cognitive and affective neuroscience2018

Cognitive control and network disruption in remitted depression: a correlate of childhood adversity.

Meghan E Quinn, Jonathan P Stange, Lisanne M Jenkins, Samantha Corwin, Sophie R DelDonno, Katie L Bessette, Robert C Welsh, Scott A Langenecker

Open access · goldAbstract read
In one paragraph

Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025
    Review
  3. Article
  4. Article
  5. Environmental and neurodevelopmental contributors to youth mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Meghan E QuinnDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Jonathan P StangeDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Lisanne M JenkinsDepartment of Psychiatry, Northwestern University, Chicago, IL, USA.
Samantha CorwinDepartment of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
Sophie R DelDonnoDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Katie L BessetteDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Robert C WelshDepartment of Psychiatry, University of Utah, UT, USA.
Scott A LangeneckerDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USNorthwestern University · USUniversity of Utah · USVanderbilt University · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Center for Clinical and Translational ScienceUL1TR000050 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AZAR, DIMITRI T, MERMELSTEIN, ROBIN J. · 2012 to 2014
$9.8M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
Training in the Neuroscience of Mental HealthT32MH067631 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RASENICK, MARK M. · 2004 to 2024
$4.8M
A High-End 3 Tesla Human MRI Scanner Dedicated to ResearchS10RR028898 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHOU, XIAOHONG JOE · 2010 to 2010
$2.9M
NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR002003NCRR NIH HHS S10 RR028898NIMH NIH HHS T32 MH018921NIMH NIH HHS T32 MH067631
6 · The paper itself

Abstract

Individuals in a major depressive episode often display impairment in cognitive control, and this impairment exists outside of the acute phase of illness. Impairment in cognitive control also has been associated with exposure to childhood adversity (CA). The current study examined whether exposure to CA can explain variance in a component of cognitive control-inhibitory control-independent of diagnostic status in young adults with and without a history of depression. Healthy control individuals (n = 40) and individuals with remitted major depressive disorder (n = 53) completed a task measuring inhibitory control, reported level of CA and completed a scanning session to assess gray matter volume and resting state connectivity in regions associated with cognitive control. The results demonstrate that higher levels of CA were associated with poorer inhibitory control, reduced right middle frontal gyrus gray matter, decreased connectivity of salience and emotion networks and increased connectivity in cognitive control networks, even after controlling for diagnostic status, residual depression symptoms and current stressors. Together, the results suggest that inhibitory control impairment and intrinsic connectivity changes may be characterized as developmental sequelae of early stress exposure.

Indexed as

AdolescentBrainCognitionEmotionsExecutive FunctionFemaleGray MatterHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleNeuropsychological TestsYoung Adult

Identifiers

PMID30285231
PMCPMC6204481
OpenAlexW2894855020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.