Trial reportJournal of Crohn's & colitis2019
Appendectomy for Therapy-Refractory Ulcerative Colitis Results in Pathological Improvement of Colonic Inflammation: Short-Term Results of the PASSION Study.
Trial report in Journal of Crohn's & colitis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05209061 (Cellular Composition of the Human Appendix Using Single-cell RNA and Single-cell ATAC-sequencing.), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cellular Composition of the Human Appendix Using Single-cell RNA and Single-cell ATAC-sequencing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Histopathological Findings of Appendix Specimens in Quiescent Ulcerative Colitis: Correlations With Clinical Outcomes in the ACCURE Trial.United European gastroenterology journal · 2026Trial
- Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial.The lancet. Gastroenterology & hepatology · 2025Trial
- Appendix in ulcerative colitis pathogenesis and therapy: An updated narrative review.World journal of gastrointestinal pathophysiology · 2026Review
- Relationship between the appendix and ulcerative colitis: A new discovery.World journal of gastrointestinal endoscopy · 2026Review
- The appendix and ulcerative colitis: from an unsolved connection to a therapeutic strategy.Translational gastroenterology and hepatology · 2026Article
- Reconsidering therapeutic strategies after biologic failure in ulcerative colitis: appendectomy versus Janus kinase inhibition.Translational gastroenterology and hepatology · 2026Article
- Peri-appendiceal inflammation is associated with appendiceal orifice stenosis and appendiceal body thickening in ulcerative colitis: A case-control study.The Journal of international medical research · 2025Article
- The Place of Appendicectomy in Inflammatory Bowel Disease-A Review.ANZ journal of surgery · 2025Review
- Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.Journal of Crohn's & colitis · 2024Review
- Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis.Digestive diseases and sciences · 2024Article
- Removing the Appendix: Prologue to Severe Clostridioides difficile Infection and Recurrence?Digestive diseases and sciences · 2023Article
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- A Compendium of Mucosal Molecular Characteristics Provides Novel Perspectives on the Treatment of Ulcerative Colitis.Journal of Crohn's & colitis · 2023Article
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls - a prospective cohort study.Alimentary pharmacology & therapeutics · 2023Article
- Clinical relevance of endoscopic peri-appendiceal red patch in ulcerative colitis patients.Therapeutic advances in gastroenterology · 2022Article
- When disease extent is not always a key parameter: Management of refractory ulcerative proctitis.Current research in pharmacology and drug discovery · 2022Review
- Article
- State-of-the-art surgery for ulcerative colitis.Langenbeck's archives of surgery · 2021Article
- Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.Mucosal immunology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe objective of this study was to examine the modulating effect of an appendectomy on the disease course of therapy-refractory ulcerative colitis [UC] patients, and to analyse appendiceal pathological characteristics predictive of pathological response.
methodsPatients with therapy-refractory UC, and referred for proctocolectomy, were invited to undergo laparoscopic appendectomy first. The primary end points were clinical response after 3 and 12 months. Secondary end points were endoscopic remission, failure, and pathologic response. Appendiceal specimens, and pre- and post-operative biopsies were histologically graded according to the validated Geboes score.
resultsThirty patients [53% male] with a median age of 40 (interquartile range [IQR], 33-47) underwent appendectomy, with a median preoperative total Mayo score of 9 [IQR, 8-11]. After 12 months, 9 patients [30%] had lasting clinical response, of whom 5 [17%] were in endoscopic remission. Pathological evaluation was possible in 28 patients. After a median of 13.0 weeks [range 7-51], pathological response was seen in 13 patients [46%], with a median decrease of 2 points [range 1-3]. Appendiceal inflammation was highly predictive of pathological response when compared with no inflammation or extensive ulcerations [85% vs 20%, p = 0.001].
conclusionsAppendectomy was effective in one-third of therapy-refractory UC patients, with a substantial proportion of patients demonstrating complete endoscopic remission after 1 year. Pathological response was seen in almost 50% of patients and was related to active inflammation in the appendix, limited disease, and shorter disease duration. These early results suggest that there is a UC patient group that may benefit from appendectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.