ArticleAmerican journal of clinical pathology2019
Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.
Article in American journal of clinical pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Paediatric Reference Intervals and Curves for Haemoglobin Estimated Using Direct Methods: A Systematic Review and Meta-Analysis.International journal of laboratory hematology · 2025Pooled it
- Hematological parameters' reference intervals in apparently healthy individuals in Saudi Arabia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Age- and sex-specific patterns of microcytic anemia in adolescence: implications for screening.European journal of pediatrics · 2026Article
- Pediatric Reference and Optimal Curves for Hemoglobin.JAMA network open · 2026Article
- Serum Magnesium Concentrations in the United States-An Updated Population Reference Interval in Children and Adults.The Journal of nutrition · 2026Article
- Ergothioneine Depletion in Peritoneal Dialysis.Kidney360 · 2026Article
- Modifications in hemoglobin levels associated with age in an outpatient population from northern italy.Scientific reports · 2025Article
- Depletion by Hemodialysis of the Antioxidant Ergothioneine.Kidney360 · 2025Article
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- Effect of lower body negative pressure on cardiac and cerebral function in postural orthostatic tachycardia syndrome: A pilot MRI assessment.Physiological reports · 2024Article
- Risk factors for cognitive impairment in middle-aged type 2 diabetic patients: a cross-sectional study.BMJ open · 2024Article
- Erythrocyte indices and localized stage II/III periodontitis in military young men and women: CHIEF oral health study.BMC oral health · 2022Article
- Hematological indices in the adult saudi population: Reference intervals by gender, age, and region.Frontiers in medicine · 2022Article
- The effect of malaria on childhood anemia in a quasi-experimental study of 7,384 twins from 23 Sub-Saharan African countries.Frontiers in public health · 2022Article
- The effect of malaria on haemoglobin concentrations: a nationally representative household fixed-effects study of 17,599 children under 5 years of age in Burkina Faso.Malaria journal · 2021Article
- Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan.International journal of hematology · 2021Article
- Establishment of age- and sex-specific reference intervals for serum liver function tests in pediatric population aged 1-<18 years: A prospective study.Journal of clinical laboratory analysis · 2021Article
- Red Cell Distribution Width, Unlike Neutrophil Lymphocyte Ratio Is Unable to Accurately Gauge Enhanced Systemic Inflammation Associated With Panoramic Imaged Carotid Plaque.Military medicine · 2021Article
- CALIPER Hematology Reference Standards (I).American journal of clinical pathology · 2020Article
- Anaemia and Its Relation to Demographic, Socio-economic and Anthropometric Factors in Rural Primary School Children in Hai Phong City, Vietnam.Nutrients · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328). Methods: Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution width were computed using piecewise regression, an evidence-based statistical procedure that identifies breakpoints. Results: The derived reference intervals were sex specific, unlike many current standards, and more precise for individuals of different ages, especially for children, adolescents, and elderly individuals, as additional breakpoints were detected for these groups. Suggested reference values for hematocrit and hemoglobin of older adult males were substantially lower than current values. Conclusions: The reference intervals provided here, based on a large, nationally representative healthy population, contribute to the ongoing transition to precision medicine.
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