ArticleAnnals of Saudi medicine
Outcome with topical sirolimus for port wine stain malformations after unsatisfactory results with pulse dye laser treatment alone.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Non-Involuting Congenital Hepatic Hemangioma: Lessons from a Case Series.Children (Basel, Switzerland) · 2025Article
- Circulating Levels of VEGF, mTOR and MAPK in Patients With Port-Wine Stains.Journal of cosmetic dermatology · 2025Article
- Efficacy and prognostic factors for successful treatment of port-wine stains by 577-nm yellow laser: a cohort study on 42 patients.Lasers in medical science · 2025Article
- Comparing the clinical efficacy of hemoporfin-mediated photodynamic therapy for port wine stains in children with prior pulsed dye laser treatment history.Frontiers in medicine · 2025Article
- [Rapamycin and HPPH Co-Loaded Nanodrug Delivered via Dissolvable Microneedles to Treat Port-Wine Stains].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Evaluating the clinical efficacy of pulsed dye laser with sirolimus for treatment of capillary malformations: A systematic review.Skin health and disease · 2024Review
- Sturge-Weber Syndrome: A Review of Pathophysiology, Genetics, Clinical Features, and Current Management Approache.The application of clinical genetics · 2023Review
- Pathogenesis of Port-Wine Stains: Directions for Future Therapies.International journal of molecular sciences · 2022Review
- Triple pass laser therapy for recalcitrant facial port wine stains.Lasers in medical science · 2022Article
- Enhanced Activation of mTOR Signaling Pathway Was Found in the Hypertrophic and Nodular Lesions of Port Wine Stains.Clinical, cosmetic and investigational dermatology · 2022Article
- Treatment of angiokeratomas of Fordyce with topical rapamycin 0.25% cream.JAAD case reports · 2021Article
- Consensus Statement for the Management and Treatment of Port-Wine Birthmarks in Sturge-Weber Syndrome.JAMA dermatology · 2021Review
- The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.International journal of molecular sciences · 2019Review
- Off-Label Topical Application of Sirolimus (Rapamycin) for Dermatological Conditions.Journal of cutaneous medicine and surgeryReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used a topical formulation of sirolimus for treating port wine stain (PWS). Although pulsed dye laser (PDL) is the current treatment of choice for PWS, fast neovascularization after treatment is a major drawback. With PDL therapy there has been insufficient improvement and frustrating side effects. The objective was to study the efficacy and safety of combining topical sirolimus with PDL as dual therapy in managing PWS. We report five PWS cases that were treated with PDL initially, followed by 0.5-1% topical sirolimus. With dual therapy there was significant improvement over a shorter duration. More published studies of topical sirolimus are needed to clarify the role of dual therapy in managing PWS associated with capillary malformations. We encourage further prospective and comparative studies with a larger sample size. SIMILAR CASES PUBLISHED: 1.
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