Evidence map›Paper›PMID 30284969›Full record

ArticleeLife2018

Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells.

Despoina Mademtzoglou, Yoko Asakura, Matthew J Borok, Sonia Alonso-Martin, Philippos Mourikis, Yusaku Kodaka, Amrudha Mohan, Atsushi Asakura, Frederic Relaix

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
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  10. A dysfunctional miR-1-TRPS1-MYOG axis drives ERMS by suppressing terminal myogenic differentiation.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Despoina MademtzoglouInserm, IMRB U955-E10, F-94010, Créteil, France.ORCID 0000-0002-4494-7234
Yoko AsakuraStem Cell Institute, Paul and Sheila Wellstone Muscular Dystrophy Center, Department of Neurology, University of Minnesota Medical School, Minneapolis, United States.ORCID 0000-0003-4107-4236
Matthew J BorokInserm, IMRB U955-E10, F-94010, Créteil, France.ORCID 0000-0003-2951-6265
Sonia Alonso-MartinInserm, IMRB U955-E10, F-94010, Créteil, France.ORCID 0000-0002-3254-0365
Philippos MourikisInserm, IMRB U955-E10, F-94010, Créteil, France.ORCID 0000-0003-3164-7109
Yusaku KodakaStem Cell Institute, Paul and Sheila Wellstone Muscular Dystrophy Center, Department of Neurology, University of Minnesota Medical School, Minneapolis, United States.ORCID 0000-0001-7993-9640
Amrudha MohanStem Cell Institute, Paul and Sheila Wellstone Muscular Dystrophy Center, Department of Neurology, University of Minnesota Medical School, Minneapolis, United States.ORCID 0000-0002-7368-9350
Atsushi AsakuraStem Cell Institute, Paul and Sheila Wellstone Muscular Dystrophy Center, Department of Neurology, University of Minnesota Medical School, Minneapolis, United States.ORCID 0000-0001-8078-1027
Frederic RelaixInserm, IMRB U955-E10, F-94010, Créteil, France.ORCID 0000-0003-1270-1472
Inserm · FRUniversity of Minnesota · US

Funding

Genetically Engineered Muscle Stem Cell Transplantation for Muscular Dystrophy...R01AR062142 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2012 to 2016
$1.6M
Engineering iPSC-Derived Skeletal Muscle and Cells for TransplantationR21AR070319 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2016 to 2017
$372k
Agence Nationale de la Recherche Bone-muscle-repair (ANR-13-BSV1- 455 0011-02),BMP-Myomass (ANR-12-BSV1-0038- 04),Satnet (ANR-15-CEAssociation Française contre les Myopathies TRANSLAMUSCLE (PROJECT 19507)Fondation pour la Recherche Médicale Grant DEQ20130326526Labex Revive ANR-10-LABX-73MyoGrad Network GK1631NIAMS NIH HHS R01 AR062142NIAMS NIH HHS R21 AR070319NIH HHS NIH R01 (1R01AR062142) and 457 NIH R21 (1R21AR070319)
6 · The paper itself

Abstract

Adult skeletal muscle maintenance and regeneration depend on efficient muscle stem cell (MuSC) functions. The mechanisms coordinating cell cycle with activation, renewal, and differentiation of MuSCs remain poorly understood. Here, we investigated how adult MuSCs are regulated by

Indexed as

Adult Stem CellsAnimalsCell Cycle CheckpointsCell DifferentiationCell ProliferationCyclin-Dependent Kinase Inhibitor p57Gene Expression Regulation, DevelopmentalMiceMuscle DevelopmentMuscle, SkeletalMyoblastsRegenerationSatellite Cells, Skeletal MuscleCdkn1c protein, mouseCyclin-Dependent Kinase Inhibitor p57cell cyclecyclin-dependent kinase inhibitorsdevelopmental biologymousemuscle regenerationp57regenerative medicinesatellite cellsstem cells

Identifiers

PMID30284969
PMCPMC6172026
OpenAlexW2895621144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.