Evidence map›Paper›PMID 30284646›Full record

ArticleClinical and experimental medicine2019

Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis.

Xiuzhen Wang, Chunshu Yang, Feng Xu, Lin Qi, Jianing Wang, Pingting Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Role of sPD-1 and sPD-Ls in the pathogenesis of connective tissue disease.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  11. Review
  12. A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Review
  15. Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritisFrontiers in cellular and infection microbiology · 2023
    Review
  16. Article
  17. Increased TIGITExperimental and therapeutic medicine · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiuzhen WangDepartment of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.
Chunshu YangDepartment of First Cancer Institute, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.
Feng XuDepartment of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.
Lin QiDepartment of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.
Jianing WangDepartment of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.
Pingting YangDepartment of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China. yangpingtingting@163.com.ORCID http://orcid.org/0000-0002-2800-7947

Funding

clinical medical research center of Shenyang, Liaoning, China 18_009-4-03Major State Research Development Program of Liaoning, China 2017225024Project for Construction of Major Discipline Platform in Universities of Liaoning province, China 2017001The Program of the Distinguished Professor of Liaoning Province, Rheumatology 2017
6 · The paper itself

Abstract

Follicular helper T(Tfh) cells and follicular regulatory T(Tfr) cells are critical for the development and maintenance of germinal center and humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of either Tfh or Tfr cells contributes to the pathogenesis of autoimmune diseases. The aim of this study was to examine the numbers of Tfh and Tfr cells in patients with rheumatoid arthritis (RA). Twenty-four patients with RA patients and 20 health controls (HCs) were enrolled in this study. We analyzed the numbers of Tfh (CD4

Indexed as

AdultAgedArthritis, RheumatoidB7-H1 AntigenCD4 AntigensCellsEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunophenotypingInterleukin-7 Receptor alpha SubunitLymphocyte CountMaleMiddle AgedProgrammed Cell Death 1 Ligand 2 ProteinB7-H1 AntigenCD274 protein, humanCD4 AntigensCXCR5 protein, humanInterleukin-7 Receptor alpha SubunitPDCD1LG2 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorReceptors, CXCR5Follicular helper T cell(Tfh)Follicular regulatory T cell(Tfr)PD-1Rheumatoid arthritisTfr/Tfh

Identifiers

PMID30284646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.