ArticleIntensive care medicine2018
Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167173 (Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Research trends and hotspots on septic shock: a bibliometric study and visualization analysis.Frontiers in medicine · 2024Pooled it
- Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Article
- Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.Age and ageing · 2026Observational
- Integrating host mRNA signatures and clinical trajectories with machine learning for risk stratification and survival prediction in sepsis: an ICU-based prospective cohort study.BMC infectious diseases · 2026Article
- Early prediction of sepsis in the ICU: a comparative analysis of multiple machine-learning algorithms using the MIMIC-III database.BMC medical informatics and decision making · 2026Article
- [Sepsis care in Germany: quality indicators on diagnostics and treatment of sepsis].Die Anaesthesiologie · 2026Article
- Evidence of immune-metabolic imbalance prior to sepsis: a prospective study in the UK Biobank.Frontiers in nutrition · 2026Article
- Fluvoxamine attenuates inflammation in experimental sepsis via novel non-canonical pathways.Inflammopharmacology · 2026Article
- Positive and unlabeled learning from hospital administrative data: a novel approach to identify sepsis cases.Health care management science · 2025Article
- Article
- Perceived Trust and Professional Identity Threat in AI-Based Clinical Decision Support Systems: Scenario-Based Experimental Study on AI Process Design Features.JMIR formative research · 2025Article
- Low expression of CD39 on monocytes predicts poor survival in sepsis patients.Journal of intensive care · 2025Article
- An AI-Based Clinical Decision Support System for Antibiotic Therapy in Sepsis (KINBIOTICS): Use Case Analysis.JMIR human factors · 2025Article
- Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.Intensive care medicine experimental · 2025Article
- Context and determinants for implementing a sepsis survivor care transition intervention reported from five health systems and home health agencies.Frontiers in medicine · 2025Article
- Prognostic value of modified shock index in sepsis.Bioinformation · 2025Article
- Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit.Open medicine (Warsaw, Poland) · 2025Article
- Association between HALP score and in-hospital mortality in sepsis patients: a multicenter retrospective cohort study with external validation.Frontiers in public health · 2025Article
- How are Long-Covid, Post-Sepsis-Syndrome and Post-Intensive-Care-Syndrome related? A conceptional approach based on the current research literature.Critical care (London, England) · 2024Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeSepsis contributes considerably to global morbidity and mortality, while reasons for its increasing incidence remain unclear. We assessed risk adjusted secular trends in sepsis and infection epidemiology in Germany.
methodsRetrospective cohort study using nationwide German hospital discharge data. We assessed incidence, outcomes and trends of hospital-treated sepsis and infections between 2010 and 2015. Sepsis was identified by explicit ICD-10 sepsis codes. As sensitivity analysis, results were compared with sepsis cases identified by implicit sepsis coding (combined infection and organ dysfunction codes).
resultsAmong 18 664 877 hospital admissions in 2015, 4 213 116 (22.6%) patients had at least one infection code. There were 320 198 patients that had explicit sepsis codes including 136 542 patients with severe sepsis and septic shock; 183 656 patients were coded as sepsis without organ dysfunction. For patients with explicitly coded sepsis (including severe sepsis), or with severe sepsis alone, mortality rates over the period 2010-2015 decreased from 26.6 to 23.5%, and from 47.8 to 41.7%, respectively.
conclusionsSepsis and infection remain significant causes of hospital admission and death in Germany. Sepsis-related mortality is higher and has declined to a lesser degree than in other high-income countries. Although infection rates steadily increased, the observed annual increase of sepsis cases seems to result, to a considerable degree, from improved coding of sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.