Evidence map›Paper›PMID 30284249›Full record

ArticleThe Journal of physiology2019

Elevation of extracellular osmolarity improves signs of myotonia congenita in vitro: a preclinical animal study.

Kerstin Hoppe, Sunisa Chaiklieng, Frank Lehmann-Horn, Karin Jurkat-Rott, Scott Wearing, Werner Klingler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Kerstin HoppeDepartment of Anaesthesia, Critical Care Medicine and Pain Therapy, University of Frankfurt, Frankfurt, Germany.ORCID 0000-0002-5789-7926
Sunisa ChaikliengDivision of Neurophysiology in the Center of Rare Diseases, Ulm University, Ulm, Germany.
Frank Lehmann-HornDivision of Neurophysiology in the Center of Rare Diseases, Ulm University, Ulm, Germany.
Karin Jurkat-RottDepartment of Neuroanaesthesiology, Neurosurgical University, Guenzburg, Germany.
Scott WearingInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Werner KlinglerInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Queensland University of Technology · AUBeijing Institute of Neurosurgery · CNGoethe University Frankfurt · DEKhon Kaen University · THUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsDuring myotonia congenita, reduced chloride (Cl ABSTRACT: Low chloride-conductance myotonia is caused by mutations in the skeletal muscle chloride (Cl

Indexed as

Osmolar ConcentrationAnimalsBumetanideDisease Models, AnimalFemaleMaleMembrane PotentialsMiceMuscle, SkeletalMyotonia CongenitaSodium Potassium Chloride Symporter InhibitorsSolute Carrier Family 12, Member 2BumetanideSlc12a2 protein, mouseSodium Potassium Chloride Symporter InhibitorsSolute Carrier Family 12, Member 2Myotonia congenitaNKCC1warm-up phenomena

Identifiers

PMID30284249
PMCPMC6312412
OpenAlexW2895093873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.