Evidence map›Paper›PMID 30284220›Full record

ArticleJournal of endocrinological investigation2019

Effects of metabolic abnormalities, hyperandrogenemia and clomiphene on liver function parameters among Chinese women with polycystic ovary syndrome: results from a randomized controlled trial.

W-Y Cai, J-S Gao, X Luo, H-L Ma, H Ge, N Liu, Q Xia, Y Wang, B-W Han, X-K Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

W-Y CaiHeilongjiang University of Chinese Medicine, Harbin, China.
J-S GaoDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
X LuoHeilongjiang University of Chinese Medicine, Harbin, China.
H-L MaDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
H GeHeilongjiang University of Chinese Medicine, Harbin, China.
N LiuHeilongjiang University of Chinese Medicine, Harbin, China.
Q XiaHeilongjiang University of Chinese Medicine, Harbin, China.
Y WangDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
B-W HanHeilongjiang University of Chinese Medicine, Harbin, China.
X-K WuDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China. xiaokewu2002@vip.sina.com.
Heilongjiang University of Chinese Medicine · CNFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine · CN

Funding

Intervention for Polycystic Ovary Syndrome Based on Traditional Chinese Medicine Theory-'Tian Gui Disorder' 2011TD006National Clinical Trial Base in Chinese Medicine Special Projects 2015B009National Clinical Trial Base in Chinese Medicine Special Projects JDZX2012036National Public Welfare Projects for Chinese Medicine 200807002National Public Welfare Projects for Chinese Medicine 201107005
6 · The paper itself

Abstract

purposeTo investigate the effects of metabolic abnormalities, hyperandrogenemia and ovulation induction by clomiphene/acupuncture on liver function parameters among women with polycystic ovary syndrome (PCOS).

methodsThis is a secondary analysis of a randomized controlled trial. All 1000 subjects were diagnosed as PCOS by modified Rotterdam criteria. Liver function parameters, metabolic panel and hormone profile were measured at baseline and after treatment. The relationship between liver parameters with metabolic, hormonal parameters and ovulation induction was examined.

resultsPCOS women with metabolic syndrome had higher liver enzyme levels but lower bilirubin and bile acid levels than without. PCOS women with hyperandrogenemia had higher liver enzyme, bilirubin levels than without. Correlation analyses showed that worsening of metabolic parameters was associated with higher liver enzyme levels but lower bilirubin and bile acid levels, while increased androgen levels were associated with higher liver enzyme, bilirubin and bile acid levels. Ovulation induction with clomiphene citrate could decrease bilirubin and bile acid levels, while acupuncture had no obvious effect on liver function.

conclusionsAmong PCOS women, metabolic abnormalities and hyperandrogenemia impaired different liver function parameters. Clomiphene could decrease the bilirubin and bile acid levels while acupuncture had no obvious effect on liver function.

Indexed as

Ovulation InductionAcupuncture TherapyAlanine TransaminaseAspartate AminotransferasesBilirubinBiomarkersCase-Control StudiesClomipheneFemaleFertility Agents, FemaleFollow-Up StudiesHumansHyperandrogenismLiverLiver Function TestsMetabolic SyndromeAlanine TransaminaseAspartate AminotransferasesBilirubinBiomarkersClomipheneFertility Agents, FemaleHyperandrogenemiaLiver functionMetabolic syndromeOvulation inductionPCOS

Identifiers

PMID30284220
OpenAlexW2894792805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.