Evidence map›Paper›PMID 30284120›Full record

ReviewDrugs & aging2018

The Role of Deprescribing in Older Adults with Chronic Kidney Disease.

Laura K Triantafylidis, Chelsea E Hawley, Laura P Perry, Julie M Paik

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drugs & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

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  15. Overcoming barriers to implementing new guideline-directed therapies for chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Laura K TriantafylidisPharmacy Department, VA Boston Healthcare System, Boston, MA, USA. Laura.Triantafylidis@va.gov.
Chelsea E HawleyPharmacy Department, VA Boston Healthcare System, Boston, MA, USA.
Laura P PerryNew England Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA.
Julie M PaikNew England Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA.
VA Boston Healthcare System · USBrigham and Women's Hospital · USHighland Hospital · US

Funding

Intramural VA VA999999
6 · The paper itself

Abstract

Older adults with chronic kidney disease (CKD) often experience polypharmacy, a recognized predictor of prescribing problems including inappropriately dosed medications, drug-drug and drug-disease interactions, morbidity and mortality. Polypharmacy is also associated with nonadherence, which leads to recurrent hospitalizations and poorer hemodialysis outcomes in CKD patients. Further complicating medication management in this vulnerable population are the physiologic changes that occur with both age and CKD. This guide for pharmacists and prescribers offers considerations in medication evaluation and management among older adults with CKD. Careful prescribing with the aid of tools such as the American Geriatrics Society Beers Criteria can support safe medication use and appropriate prescribing. Polypharmacy may be systematically addressed through 'deprescribing,' an evidence-based process that enables identification and elimination of unnecessary or inappropriate medications. Detailed guidance for deprescribing in older adults with CKD has not been published previously. We highlight three specific targets for medication optimization and deprescribing in older adults with CKD: (1) proton pump inhibitors, (2) oral hypoglycemic agents, including newer classes of agents, and (3) statins. These medication classes have been chosen as they represent three of the most commonly prescribed classes of medications in the United States. For each area, we review considerations for medication use in older adults with CKD and provide strategies to avoid, modify, or discontinue these medications when clinically indicated. By utilizing deprescribing techniques, pharmacists are well positioned to help decrease the medication burden in older adults with CKD, thereby potentially reducing the risk of morbidity and mortality associated with polypharmacy.

Indexed as

DeprescriptionsPolypharmacyAgedDrug InteractionsHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsInappropriate PrescribingPharmacistsPotentially Inappropriate Medication ListProton Pump InhibitorsRenal Insufficiency, ChronicHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsProton Pump Inhibitors

Identifiers

PMID30284120
PMCPMC8150926
OpenAlexW2895265342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.