Evidence map›Paper›PMID 30284107›Full record

ArticleMolecular diversity2019

Design, synthesis and in vitro evaluation of a Dopa-organoboron compound that acts as a bladder relaxant through non-catecholamine receptors.

Ana L Ocampo-Néstor, Ruth M López-Mayorga, Enrique F Castillo-Henkel, Itzia I Padilla-Martínez, José G Trujillo-Ferrara, Marvin A Soriano-Ursúa

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. In silico identification of a biarylamine acting as agonist at human βNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  2. Review
  3. Article
  4. Interactions of a boron-containing levodopa derivative on DJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ana L Ocampo-NéstorDepartamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
Ruth M López-MayorgaDepartamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
Enrique F Castillo-HenkelDepartamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
Itzia I Padilla-MartínezUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Avenida Acueducto s/n, Barrio La Laguna Ticomán, 07340, México, Mexico.
José G Trujillo-FerraraDepartamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico. jtrujillo@ipn.mx.
Marvin A Soriano-UrsúaDepartamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico. msoriano@ipn.mx.ORCID http://orcid.org/0000-0002-6529-1502
Instituto Politécnico Nacional · MX

Funding

Consejo Nacional de Ciencia y Tecnología CB235785Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional M1930
6 · The paper itself

Abstract

Bladder relaxation through drug administration is an interesting topic in medicinal and combinatorial chemistry. In fact, compounds targeting catecholamine receptors [dopamine receptors and beta-adrenergic receptors (βAR) expressed in the bladder] are among the compounds commonly employed for this purpose. In particular, recent investigations have tended to focus on the β

Indexed as

BoronDihydroxyphenylalanineParasympatholyticsAnimalsAortaDrug DesignIn Vitro TechniquesMaleModels, MolecularMuscle, SmoothRats, WistarReceptors, CatecholamineUrinary BladderBoronDihydroxyphenylalanineParasympatholyticsReceptors, CatecholamineAdrenoceptorBladder relaxationBoronDockingDrug designMolecular modeling

Identifiers

PMID30284107
OpenAlexW2895356993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.