Evidence map›Paper›PMID 30284064›Full record

ArticleEuropean journal of nutrition2019

Sugar-sweetened beverage consumption and incidence of breast cancer: the Seguimiento Universidad de Navarra (SUN) Project.

A Romanos-Nanclares, Estefania Toledo, I Gardeazabal, J J Jiménez-Moleón, M A Martínez-González, A Gea

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Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A Romanos-NanclaresUniversity of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain.
Estefania ToledoUniversity of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain. etoledo@unav.es.ORCID http://orcid.org/0000-0002-6263-4434
I GardeazabalUniversity of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain.
J J Jiménez-MoleónCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
M A Martínez-GonzálezUniversity of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain.
A GeaUniversity of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain.

Funding

Departamento de Salud del Gobierno de Navarra 122/2014Departamento de Salud del Gobierno de Navarra 41/2016Departamento de Salud del Gobierno de Navarra 45/2011European Regional Development Fund 06/0045Instituto de Salud Carlos III PI10/02293Instituto de Salud Carlos III PI10/02658Instituto de Salud Carlos III PI13/00615Instituto de Salud Carlos III PI14/01668Instituto de Salud Carlos III PI14/01764Instituto de Salud Carlos III PI14/01798Instituto de Salud Carlos III PI17/01795Red Temática de Investigación Cardiovascular G03/140
6 · The paper itself

Abstract

purposeBreast cancer (BC) incidence is increasing worldwide. Higher insulin resistance may potentially lead to an increased risk of BC. Sugar-sweetened beverages (SSB) are an acknowledged dietary factor that increases insulin resistance. However, the association between SSB and BC has not been widely explored. We evaluated the association between baseline consumption of SSB and the incidence of BC among relatively young women in a cohort of Spanish university graduates.

methodsWe evaluated 10,713 middle-aged, Spanish female university graduates (median age 33) from the Seguimiento Universidad de Navarra (SUN) cohort, initially free of BC. SSB consumption was collected at baseline using a validated 136-item semi-quantitative food-frequency questionnaire. Incidence of BC was confirmed by a trained oncologist using medical records. We fitted Cox regression models to assess the relationship between baseline categories of SSB consumption and the incidence of BC during follow-up. We stratified the analyses by menopausal status.

resultsDuring 106,189 person-years follow-up, 100 incident cases of BC were confirmed. Among postmenopausal women, regular consumption of SSB was associated with a significantly higher incidence of BC (HR 2.12; 95% CI 1.02, 4.41) in the fully adjusted model, compared to women who never or seldom consumed SSB. No association was found among premenopausal women (HR 1.16; 95% CI 0.66, 2.07).

conclusionsEven though the number of cases was small, in this Mediterranean cohort, we observed a direct association between SSB consumption and BC risk among postmenopausal women. Nonetheless further larger longitudinal studies are needed to support this association.

Indexed as

AdultBreast NeoplasmsCohort StudiesFemaleFollow-Up StudiesHumansIncidenceRisk FactorsSpainSugar-Sweetened BeveragesSurveys and QuestionnairesBreast cancerCohortPrimary preventionSugar-sweetened beverage

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.