ArticleLung2018
Endothelial Function in COPD Is in an Intermediate Position Between Healthy Subjects and Coronary Artery Disease Patients and Is Related to Physical Activity.
Article in Lung, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- A Cross-Sectional Study Evaluating the Association of Brachial Artery Flow Mediated Vasodilation with Physical Activity Measured by Accelerometry in Patients with the Overlap of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- Chronic Obstructive Pulmonary Disease and the Cardiovascular System: Vascular Repair and Regeneration as a Therapeutic Target.Frontiers in cardiovascular medicine · 2021Review
- Vascular Function in Patients After Myocardial Infarction: The Importance of Physical Activity.Frontiers in physiology · 2021Article
- Supervised exercise training improves endothelial function in COPD patients: a method to reduce cardiovascular risk?ERJ open research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischemic heart disease. Endothelial dysfunction may play a role in the onset of cardiovascular event. Previous studies showed an impaired endothelial function (measured by flow-mediated dilation, FMD) in COPD patients compared to healthy subjects. To the best of our knowledge no study has compared FMD in COPD and in cardiac (coronary artery disease, CAD) patients. We aimed to assess FMD in healthy subjects, COPD, CAD, and COPD + CAD. The main result is that FMD in COPD is reduced and is in an intermediate position between healthy subjects and CAD or COPD + CAD; this impairment can contribute to explain the higher prevalence of cardiovascular disease in COPD. The only determinant independently associated with FMD in all subjects is the physical activity level, irrespective of the traditional risk factors (i.e., smoke, dyslipidemia, hypertension).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.