Evidence map›Paper›PMID 30283981›Full record

Trial reportPsychopharmacology2018

The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers.

Amy Ronaldson, Livia A Carvalho, Karen Kostich, Antonio Ivan Lazzarino, Livia Urbanova, Andrew Steptoe

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Effects of the prophylactic use of escitalopram on the prognosis and the plasma copeptin level in patients with acute cerebral infarction.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amy RonaldsonResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK. a.ronaldson@ucl.ac.uk.ORCID http://orcid.org/0000-0001-8369-9168
Livia A CarvalhoDepartment of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
Karen KostichResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Antonio Ivan LazzarinoResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Livia UrbanovaResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Andrew SteptoeResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
University College London · GBQueen Mary University of London · GB

Funding

SOLID STATE STUDIES OF PHYSIOLOGICALLY IMPORTANT MOLECULESZ01HL001005 · NHLBI · HEART, LUNG, AND BLOOD INSTITUTE · PI SILVERTON, J V · 1985 to 1995
–
British Heart Foundation FS/13/40/30343British Heart Foundation RG/10/05/28296
6 · The paper itself

Abstract

rationaleHyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been widely reported in depression, and evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might exert their therapeutic effects through altering cortisol secretion.

objectiveThis study assessed the effects of SSRI administration on diurnal cortisol secretion in healthy volunteers.

methodsSixty-four healthy men and women were randomised to receive either 10 mg escitalopram or placebo for six days in a double-blind fashion. On day six of medication, saliva samples were obtained at home for measurement of diurnal cortisol parameters (cortisol slope, cortisol awakening response, total daily cortisol output).

resultsWomen receiving escitalopram had significantly steeper cortisol slopes across the day compared with those receiving placebo (F(1, 36) = 7.54, p = 0.009). This alteration in cortisol slope was driven by increases in waking cortisol levels (F(1, 35) = 9.21, p = 0.005). Escitalopram did not have any significant effect on the cortisol awakening response or the total daily cortisol output.

conclusionsFlattened cortisol slopes have been seen in depression. The results of this study suggest that escitalopram might exert its therapeutic effect in women in part through correction of a flattened diurnal cortisol rhythm.

Indexed as

AdultCircadian RhythmCitalopramDouble-Blind MethodFemaleHealthy VolunteersHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemSalivaSelective Serotonin Reuptake InhibitorsYoung AdultCitalopramHydrocortisoneSelective Serotonin Reuptake InhibitorsAntidepressantsCortisolDepressionEscitalopramHPA axisSSRIs

Identifiers

PMID30283981
PMCPMC6267127
OpenAlexW2895596692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.