ArticleChemical communications (Cambridge, England)2018
Asymmetric synthesis via stereospecific C-N and C-O bond activation of alkyl amine and alcohol derivatives.
Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Benzyl thioether formation merging copper catalysis.RSC advances · 2021Article
- Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides.Molecules (Basel, Switzerland) · 2021Article
- Chirality memory of α-methylene-π-allyl iridium species.Chemical science · 2021Article
- Dissection of Alkylpyridinium Structures to Understand Deamination Reactions.ACS catalysis · 2021Article
- Nickel-Catalyzed, Stereospecific C-C and C-B Cross-Couplings via C-N and C-O Bond Activation.ACS catalysis · 2021Article
- Nickel-catalyzed C-O/N-H, C-S/N-H, and C-CN/N-H annulation of aromatic amides with alkynes: C-O, C-S, and C-CN activation.Chemical science · 2020Article
- Stereoselectivity in Pd-catalysed cross-coupling reactions of enantioenriched nucleophiles.Nature reviews. Chemistry · 2020Article
- Sequential C-O decarboxylative vinylation/C-H arylation of cyclic oxalatesChemical science · 2020Article
- A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters.Chem · 2020Article
- A Unified Explanation for Chemoselectivity and Stereospecificity of Ni-Catalyzed Kumada and Cross-Electrophile Coupling Reactions of Benzylic Ethers: A Combined Computational and Experimental Study.Journal of the American Chemical Society · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
This perspective showcases our development of benzylic and allylic amine and alcohol derivatives as electrophiles for stereospecific, nickel-catalyzed cross-coupling reactions, as well as the prior art that inspired our efforts. The success of our effort has relied on the use of benzyl ammonium triflates as electrophiles for cross-couplings via C-N bond activation and benzylic and allylic carboxylates for cross-couplings via C-O bond activation. Our work, along with others' exciting discoveries, has demonstrated the potential of stereospecific, nickel-catalyzed cross-couplings of alkyl electrophiles in asymmetric synthesis, and enables efficient generation of both tertiary and quaternary stereocenters.
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Registered trials
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