Evidence map›Paper›PMID 30283899›Full record

ArticleJBMR plus2018

Differential Adaptive Response of Growing Bones From Two Female Inbred Mouse Strains to Voluntary Cage-Wheel Running.

Stephen H Schlecht, Melissa A Ramcharan, Yueqin Yang, Lauren M Smith, Erin Mr Bigelow, Bonnie T Nolan, Drew E Moss, Maureen J Devlin, Karl J Jepsen

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Morphology of Mouse Anterior Cruciate Ligament-Complex Changes Following Exercise During Pubertal Growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Stephen H SchlechtDepartment of Orthopaedic Surgery University of Michigan Ann Arbor MI USA.
Melissa A RamcharanUS Food and Drug Administration Silver Spring MD USA.
Yueqin YangWuhan Sports University Wuhan China.
Lauren M SmithSchool of Public Health University of Michigan Ann Arbor MI USA.
Erin Mr BigelowDepartment of Orthopaedic Surgery University of Michigan Ann Arbor MI USA.
Bonnie T NolanDepartment of Orthopaedic Surgery University of Michigan Ann Arbor MI USA.
Drew E MossDepartment of Orthopaedic Surgery University of Michigan Ann Arbor MI USA.
Maureen J DevlinDepartment of Anthropology University of Michigan Ann Arbor MI USA.
Karl J JepsenDepartment of Orthopaedic Surgery University of Michigan Ann Arbor MI USA.
University of Michigan–Ann Arbor · USUnited States Food and Drug Administration · USWuhan Sports University · CN

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
GENETIC DETERMINATION OF SKELETAL FRAGILITYR01AR044927 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JEPSEN, KARL J · 2002 to 2014
$4.3M
Phoenix / X-ray nanoTOMS10RR026336 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JEPSEN, KARL J · 2011 to 2011
$562k
Natural Variation in the Growth and Development of the ACL ComplexK99AR070903 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLECHT, STEPHEN · 2017 to 2018
$184k
NCRR NIH HHS S10 RR026336NIAMS NIH HHS K99 AR070903NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR044927NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

The phenotypic response of bones differing in morphological, compositional, and mechanical traits to an increase in loading during growth is not well understood. We tested whether bones of two inbred mouse strains that assemble differing sets of traits to achieve mechanical homeostasis at adulthood would show divergent responses to voluntary cage-wheel running. Female A/J and C57BL6/J (B6) 4-week-old mice were provided unrestricted access to a standard cage-wheel for 4 weeks. A/J mice have narrow and highly mineralized femora and B6 mice have wide and less mineralized femora. Both strains averaged 2 to 9.5 km of running per day, with the average-distance run between strains not significantly different (

Indexed as

A/J AND C57BL6/J MICEBONE FUNCTIONBONE PHENOTYPEMECHANICAL LOADINGVOLUNTARY CAGE‐WHEEL RUNNING

Identifiers

PMID30283899
PMCPMC6124195
OpenAlexW2783993969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.