Evidence map›Paper›PMID 30283877›Full record

ArticleJBMR plus2017

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation.

Andrea M Brum, Cindy S van der Leije, Marijke Schreuders-Koedam, Jeroen Verhoeven, Mark Janssen, Dick Hw Dekkers, Jeroen Aa Demmers, Marco Eijken, Jeroen van de Peppel, Johannes Ptm van Leeuwen and 1 more

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Andrea M BrumDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Cindy S van der LeijeDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Marijke Schreuders-KoedamDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Jeroen VerhoevenDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Mark JanssenArcarios BV Rotterdam the Netherlands.
Dick Hw DekkersProteomics Center Erasmus University Medical Center Rotterdam The Netherlands.
Jeroen Aa DemmersProteomics Center Erasmus University Medical Center Rotterdam The Netherlands.
Marco EijkenArcarios BV Rotterdam the Netherlands.
Jeroen van de PeppelDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Johannes Ptm van LeeuwenDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Bram Cj van der EerdenDepartment of Internal Medicine School of Molecular Medicine Erasmus University Medical Center Rotterdam the Netherlands.
Erasmus MC · NLArcadis (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. The bone building cells, osteoblasts, are derived from mesenchymal stromal cells (MSCs); however, with increasing age osteogenic differentiation is diminished and more adipocytes are seen in the bone marrow, suggesting a shift in MSC lineage commitment. Identification of specific factors that stimulate osteoblast differentiation from human MSCs may deliver therapeutic targets to treat osteoporosis. The aim of this study was to identify novel genes involved in osteoblast differentiation of human bone marrow-derived MSCs (hMSCs). We identified the gene chloride intracellular channel protein 3 (

Indexed as

BONECLIC3DIFFERENTIATIONLINEAGE DECISION MAKINGMESENCHYMAL STEM CELLOSTEOBLAST

Identifiers

PMID30283877
PMCPMC6124162
OpenAlexW859329509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.