Evidence map›Paper›PMID 30283740›Full record

ArticleEuropean thyroid journal2018

Prognostic Value of Stimulated Thyroglobulin Levels at the Time of Radioiodine Administration in Differentiated Thyroid Cancer.

Mathieu Spaas, Brigitte Decallonne, Annouschka Laenen, Jaak Billen, Sandra Nuyts

Open access · bronzeAbstract read
In one paragraph

Article in European thyroid journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mathieu SpaasDepartment of Radiation Oncology, KU Leuven - University of Leuven, University Hospitals Leuven, Leuven, Belgium.
Brigitte DecallonneDepartment of Endocrinology and Internal Medicine, KU Leuven - University of Leuven, University Hospitals Leuven, Leuven, Belgium.
Annouschka LaenenLeuven Biostatistics and Statistical Bioinformatics Centre, Leuven, Belgium.
Jaak BillenDepartment of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Sandra NuytsDepartment of Radiation Oncology, KU Leuven - University of Leuven, University Hospitals Leuven, Leuven, Belgium.
KU Leuven · BEStatistics Belgium · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prognostic value of stimulated thyroglobulin (sTg) and Tg-related parameters prior to and immediately after radioactive iodine (RAI) administration was assessed in a cohort of patients presenting with differentiated thyroid cancer (DTC) as a predictor of recurrent or progressive structural disease.

methodsClinical records of 180 DTC patients were retrospectively reviewed, and serum TSH, Tg, and Tg antibodies were recorded just before RAI administration (pre-) and at the time of whole body scanning (post-). Based on the results of initial staging and RAI scintigraphy, patients were divided into two groups: those who were considered to be structurally disease-free after thyroidectomy and RAI (group 1) and those who were not (group 2). Univariate analyses were performed for pre-Tg, ratioTg (post-Tg/pre-Tg), and other clinical and pathological markers for long-term outcome, as well as separate bivariate analyses focusing on pre-Tg to correct for possible confounders. Different pre-Tg cut-off values for predicting structural disease recurrence were assessed in a subgroup of patients in group 1 prepared with thyroid hormone withdrawal.

resultsIn group 1, (

conclusionThe sTg value at the time of RAI administration may be helpful in predicting structural disease recurrence in patients with DTC.

Indexed as

Differentiated thyroid cancerRadioiodine administrationThyroglobulin

Identifiers

PMID30283740
PMCPMC6140596
OpenAlexW2811380615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.