ArticleEvolution letters2017
Friendly foes: The evolution of host protection by a parasite.
Article in Evolution letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Simultaneous and Sequential Coexposures ofmicroPublication biology · 2026Article
- Host Transcriptomics Reveal Reduction in Defence-Reproduction Trade-Offs During Coinfection.Molecular ecology · 2025Article
- Characterizing the evolution of defense in a tripartite marine symbiosis using adaptive dynamics.Evolution letters · 2025Article
- Tolerance-conferring defensive symbionts and the evolution of parasite virulence.Evolution letters · 2023Article
- Complex networks of parasites and pollinators: moving towards a healthy balance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Social information use shapes the coevolution of sociality and virulence.Evolution; international journal of organic evolution · 2022Article
- Glochidial infection by the endangered Margaritifera margaritifera (Mollusca) increased survival of salmonid host (Pisces) during experimental Flavobacterium disease outbreak.Parasitology research · 2021Article
- Microbial evolution and transitions along the parasite-mutualist continuum.Nature reviews. Microbiology · 2021Review
- In Vivo Microbial Coevolution Favors Host Protection and Plastic Downregulation of Immunity.Molecular biology and evolution · 2021Article
- Temperature stress induces mites to help their carrion beetle hosts by eliminating rival blowflies.eLife · 2020Article
- Concomitant Immunity and Worm Senescence May Drive Schistosomiasis Epidemiological Patterns: An Eco-Evolutionary Perspective.Frontiers in immunology · 2020Review
- Comparative iTRAQ-based quantitative proteomic analysis of the Chinese grass shrimp (Palaemonetes sinensis) infected with the isopod parasite Tachaea chinensis.Parasites & vectors · 2019Article
- Shifts along the parasite-mutualist continuum are opposed by fundamental trade-offs.Proceedings. Biological sciences · 2019Article
- The evolution of juvenile susceptibility to infectious disease.Proceedings. Biological sciences · 2018Article
- Mutual fitness benefits arise during coevolution in a nematode-defensive microbe model.Evolution letters · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hosts are often infected by multiple parasite species, yet the ecological and evolutionary implications of the interactions between hosts and coinfecting parasites are largely unknown. Most theoretical models of evolution among coinfecting parasites focus on the evolution of virulence, but parasites may also evolve to protect their hosts by reducing susceptibility (i.e., conferring resistance) to other parasites or reducing the virulence of coinfecting parasites (i.e., conferring tolerance). Here, we analyze the eco-evolutionary dynamics of parasite-conferred resistance and tolerance using coinfection models. We show that both parasite-conferred resistance and tolerance can evolve for a wide range of underlying trade-offs. The shape and strength of the trade-off qualitatively affects the outcome causing shifts between the minimisation or maximization of protection, intermediate stable strategies, evolutionary branching, and bistability. Furthermore, we find that a protected dimorphism can readily evolve for parasite-conferred resistance, but find no evidence of evolutionary branching for parasite-conferred tolerance, in general agreement with previous work on host evolution. These results provide novel insights into the evolution of parasite-conferred resistance and tolerance, and suggest clues to the underlying trade-offs in recent experimental work on microbe-mediated protection. More generally, our results highlight the context dependence of host-parasite relationships in complex communities.
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