Evidence map›Paper›PMID 30283632›Full record

ArticleJournal of materials chemistry. B2018

Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering.

Nadav Amdursky, Manuel M Mazo, Michael R Thomas, Eleanor J Humphrey, Jennifer L Puetzer, Jean-Philippe St-Pierre, Stacey C Skaalure, Robert M Richardson, Cesare M Terracciano, Molly M Stevens

Open access · hybridAbstract read
In one paragraph

Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Amyloid-Based Albumin Hydrogels.Advanced healthcare materials · 2023
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Nadav Amdursky *Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Manuel M Mazo *Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Michael R ThomasDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Eleanor J HumphreyNational Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, SW7 2AZ, UK.
Jennifer L PuetzerDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Jean-Philippe St-PierreDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Stacey C SkaalureDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Robert M RichardsonH H Wills Physics Laboratory, University of Bristol, Bristol, BS8 1TL, UK.
Cesare M TerraccianoNational Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, SW7 2AZ, UK.
Molly M StevensDepartment of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
Imperial Valley College · USLung Institute · USUniversity of Bristol · GB

Funding

British Heart Foundation RM/13/1/30157European Research Council 616417Wellcome Trust 098411
6 · The paper itself

Abstract

Hydrogels are promising materials for mimicking the extra-cellular environment. Here, we present a simple methodology for the formation of a free-standing viscoelastic hydrogel from the abundant and low cost protein serum albumin. We show that the mechanical properties of the hydrogel exhibit a complicated behaviour as a function of the weight fraction of the protein component. We further use X-ray scattering to shed light on the mechanism of gelation from the formation of a fibrillary network at low weight fractions to interconnected aggregates at higher weight fractions. Given the match between our hydrogel elasticity and that of the myocardium, we investigated its potential for supporting cardiac cells

Identifiers

PMID30283632
PMCPMC6166857
OpenAlexW2888020657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.