Evidence map›Paper›PMID 30283364›Full record

ArticleFrontiers in psychiatry2018

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile.

Vinod Kumar, Willma E Polgar, Gerta Cami-Kobeci, Mark P Thomas, Taline V Khroyan, Lawrence Toll, Stephen M Husbands

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Vinod KumarDepartment of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India.
Willma E PolgarSRI International, Menlo Park, CA, United States.
Gerta Cami-KobeciDepartment of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom.
Mark P ThomasDepartment of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom.
Taline V KhroyanSRI International, Menlo Park, CA, United States.
Lawrence TollDepartment of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL, United States.
Stephen M HusbandsDepartment of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom.
University of Bath · GBCentral University of Punjab · INFlorida Atlantic University · USMenlo School · USSRI International · US

Funding

MIXED NOP/MU COMPOUNDS AND THE INVOLVEMENT OF THEIR RECEPTORS IN ANALGESIAR01DA023281 · NIDA · TORREY PINES INST FOR MOLECULAR STUDIES · PI TOLL, LAWRENCE R · 2007 to 2021
$6.4M
Narcotic Drug and Opioid Peptide Basic Research projectP01DA000254 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODS, JAMES H · 2003 to 2006
$5.0M
DISCOVERY OF NEW TREATMENTS FOR INTRAVENOUS DRUG ABUSER01DA007315 · NIDA · UNIVERSITY OF BRISTOL · PI HUSBANDS, STEPHEN M, TRAYNOR, JOHN R. · 1991 to 2019
$4.8M
TRAINING IN NEUROSCIENCE RELATED TO DRUG ABUSET32DA007315 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOOK, VIVIAN Y. H · 2000 to 2013
$2.7M
Derivatives of Naltrexone as Opioid PharmacotherapiesR01DA020469 · NIDA · UNIVERSITY OF BATH · PI HUSBANDS, STEPHEN M · 2008 to 2010
$672k
NIDA NIH HHS P01 DA000254NIDA NIH HHS R01 DA007315NIDA NIH HHS R01 DA020469NIDA NIH HHS R01 DA023281NIDA NIH HHS T32 DA007315Wellcome Trust
6 · The paper itself

Abstract

A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors. The majority of the new ligands displayed high binding affinities for the three opioid receptors, and moderate affinity for NOP receptors. The affinities for NOP receptors are of particular interest as most classical opioid ligands do not bind to NOP receptors. The predominant activity in the [

Indexed as

analgesicskappa opioid receptormu opioid receptorsnociceptinopioidORL-1

Identifiers

PMID30283364
PMCPMC6156383
OpenAlexW2889595272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.