ReviewFrontiers in aging neuroscience2018
Healthy Aging and Dementia: Two Roads Diverging in Midlife?
Review in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.F1000Research · 2020Pooled it
- Lifetime Patterns of Earned Income Tax Credit Eligibility and Cognition: A Sequence Analysis Approach.American journal of preventive medicine · 2026Article
- Socioeconomic status and cognitive function in older adults: the mediating roles of social activity and loneliness in three aging cohorts.BMC public health · 2026Article
- Genetic risk of Alzheimer's disease is associated with loss of brain network segregation in midlife.Communications biology · 2026Article
- Co-exploring how environments shape brain health through a planetary health lens: a photovoice study in Auckland, Aotearoa New Zealand.BMJ open · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- The impact of dual-tasking on mnestic performance in normal ageing.Scientific reports · 2025Article
- Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study.NeuroImage · 2025Article
- Training for dementia care and support in rural and remote Australia: appraisals from a nationwide workforce survey.BMC geriatrics · 2025Article
- Neutrophil-to-Lymphocyte Ratio in the Alzheimer's Disease Continuum.International journal of molecular sciences · 2025Review
- Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial.Pilot and feasibility studies · 2025Article
- Exposure to neighborhood concentrated poverty is associated with faster decline in episodic memory among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging.Frontiers in aging neuroscience · 2025Article
- Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Review
- Exploring the Distinct Effect of Age at Onset and Caudate Denervation on Cognitive Deficits in Early Parkinson's Disease.Aging and disease · 2024Article
- Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants.Nature medicine · 2024Article
- A Subtype Perspective on Cognitive Trajectories in Healthy Aging.Brain sciences · 2024Article
- Modeling the neurocognitive dynamics of language across the lifespan.Human brain mapping · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia, particularly Alzheimer's disease (AD), is a growing pandemic that presents profound challenges to healthcare systems, families, and societies throughout the world. By 2050, the number of people living with dementia worldwide could almost triple, from 47 to 132 million, with associated costs rising to $3 trillion. To reduce the future incidence of dementia, there is an immediate need for interventions that target the disease process from its earliest stages. Research programs are increasingly starting to focus on midlife as a critical period for the beginning of AD-related pathology, yet the indicators of the incipient disease process in asymptomatic individuals remain poorly understood. We address this important knowledge gap by examining evidence for cognitive and structural brain changes that may differentiate, from midlife, healthy aging and pathological AD-related processes. This review crystallizes emerging trends for divergence between the two and highlights current limitations and opportunities for future research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.