ArticleNigerian journal of surgery : official publication of the Nigerian Surgical Research Society
Evaluation of Immunohistochemical Profile of Breast Cancer for Prognostics and Therapeutic Use.
Article in Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Investigation of immunohistochemical marker expression in breast cancer of varying severity and construction of a predictive model.Translational cancer research · 2026Article
- Molecular Subtypes and Ki-67 index in Breast Carcinoma with Special Emphasis on Triple Negative Breast Cancer. A 3-year Study in a Tertiary Care Center.Indian journal of surgical oncology · 2025Article
- Ramipril ameliorates endometriosis by inducing oxidative stress-mediated apoptosis in the wistar rat.Journal of molecular histology · 2025Article
- Association of Breast Cancer Subtypes and Clinicopathological Factors with Axillary Lymph Node Positivity Amongst Women with Breast Cancer in Rajasthan: An Observational Analytical Study.Indian journal of surgical oncology · 2024Article
- Predominance of CD4+ T cells in metastatic cervical lymph nodes in papillary thyroid carcinoma.Endocrine connections · 2024Article
- Improving Invasive Breast Cancer Care Using Machine Learning Technology.Journal of biomedical research & environmental sciences · 2022Article
- Article
- Expression of p53 and p16 in Carcinoma Breast Tissue: Depicts Prognostic Significance or Coincidence.Cureus · 2021Article
- Artificial intelligence-based analysis for immunohistochemistry staining of immune checkpoints to predict resected non-small cell lung cancer survival and relapse.Translational lung cancer research · 2021Article
- Current Achievements and Applications of Transcriptomics in Personalized Cancer Medicine.International journal of molecular sciences · 2021Review
- Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria.World journal of clinical oncology · 2020Article
- Breast cancer in togolese women: immunohistochemistry subtypes.BMC women's health · 2020Article
- Liquid biopsy for the detection and management of surgically resectable tumors.Langenbeck's archives of surgery · 2019Review
- Role of Glutathione S-Transferase M1 and Glutathione S Transferase Theta 1 Gene Polymorphism, Histopathological, and Immunohistochemistry in Carcinoma Breast.International journal of applied & basic medical researchArticle
- Cutaneous Presentations of Metastatic Carcinoma Breast: A Case Series.Indian dermatology online journalArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBreast cancer is leading cancer in women, and the incidence of breast cancer in India is on the rise. The most common histologic type of breast cancer is infiltrating ductal carcinoma. Prognostic and predictive factors are used in the management of breast cancer. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2/neu) are immunohistochemical markers of prognosis as well as predictors of response to therapy. AIMS AND
objectivesThe study was conducted to evaluate ER, PR, and HER2/neu expressions in invasive ductal carcinomas of the breast by immunohistochemistry, to explore the correlation of these markers to each other and to various clinicopathological parameters: age of the patient, histological grade, tumor size, and lymph node metastasis. MATERIALS AND
methodsThis prospective study was conducted on 100 cases of infiltrating ductal carcinoma. Slides were prepared from blocks containing cancer tissue, and immunohistochemical staining was done for ER, PR, and HER2/neu expressions. Interpretation of expressions was done using Allred scoring system for ER/PR and the American Society of Clinical Oncology/College of American Pathologists guidelines for HER2/neu. Statistical analysis was performed to determine the statistical significance by applying Chi-square test.
resultsMajority of tumors were ER and PR positive and HER2/neu negative. ER and PR correlated significantly with age, tumor size, and tumor grade; whereas, HER2/neu correlated significantly with tumor size only. No association was seen with axillary lymph node metastasis. ER and PR expression correlated with each other, but none correlated with HER2/neu.
conclusionsAs the majority of the tumors are ER, PR positive and since ER and PR correlate with each other as well as with age, tumor size, and grade. Therefore, routine assessment of hormone receptors is recommended for prognostic and therapeutic information in breast cancer cases.
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