Evidence map›Paper›PMID 30283168›Full record

ArticleAnesthesia, essays and researches

Comparison of Palonosetron with Granisetron for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Abdominal Surgery.

Sifna Tahir, Altaf Ahmad Mir, Abdul Hameed

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesia, essays and researches. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04810494 (Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. A Prospective Double Blind Randomized Controlled Study.), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04810494 phase4withdrawnnot on this map

Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. A Prospective Double Blind Randomized Controlled Study.

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2022 to 2023Enrolled0ConditionsPostoperative Nausea and VomitingArms2% Lidocaine HCl topical solution, 0.9% Sodium chloride
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sifna TahirDepartment of Anesthesiology and Critical Care, GMC, Srinagar, Jammu and Kashmir, India.
Altaf Ahmad MirDepartment of Biochemistry, ESICMC and H, Hyderabad, Telangana.
Abdul HameedDepartment of Anesthesiology and Critical Care, GMC, Srinagar, Jammu and Kashmir, India.
Post Graduate Institute of Medical Education and Research · INGovernment Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients undergoing laparoscopic surgeries, postoperative nausea and vomiting (PONV) is a serious concern. With an incidence of 46%-72%, PONV hampers the postoperative recovery in spite of the availability of many antiemetic drugs. The purpose of this study was to prospectively evaluate the efficacy of palonosetron and granisetron for the prevention of PONV in patients undergoing laparoscopic abdominal surgery.

aimsThe aim of this study was to evaluate and compare the efficacy of palonosetron and granisetron in preventing PONV and to compare the duration of action and side effects in patients undergoing laparoscopic abdominal surgery under general anesthesia. SETTINGS AND

designEighty patients who were comparable in all aspects were considered for this study. After their consent, they participated in this prospective, randomized, double-blinded, comparative study. MATERIALS AND

methodsIn this observational study, 80 patients of either gender who were undergoing laparoscopic abdominal surgery under general anesthesia were enrolled in the study. Based on computer randomization, these patients were divided equally into two groups of 40 patients each in double-blinded manner. The treatments were given intravenously 5 min before induction of anesthesia. The episodes of PONV, severity of nausea/vomiting, and side effects were observed during the first 48 h after surgery. STATISTICAL TESTS: At the end of study, results were compiled and SPSS

resultsThe incidence of PONV during 0-2 h in the postoperative period was 15% with palonosetron and 27.5% with granisetron; the incidence during 2-24 h postoperatively was 20% with palonosetron and 30% with granisetron. Both palonosetron and granisetron had comparable effectiveness as antiemetic during the early postoperative periods (0-24 h). During 24-48 h, the incidence was 17.5% and 37.5%, respectively (

conclusionThere were no significant differences in the overall incidence of PONV and complete responders for palonosetron and granisetron group in the early recovery period. However, due to its prolonged duration of action, palonosetron was more effective than granisetron for long-term prevention of PONV after laparoscopic abdominal surgery.

Indexed as

5-hydroxytryptamine type 3 receptor antagonistgranisetronlaparoscopic abdominal surgerylaparoscopypalonosetronpostoperative nausea and vomiting

Identifiers

PMID30283168
PMCPMC6157227
OpenAlexW2891432179

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.