Evidence map›Paper›PMID 30283133›Full record

ArticleNature2018

Crystal structure of a membrane-bound O-acyltransferase.

Dan Ma, Zhizhi Wang, Christopher N Merrikh, Kevin S Lang, Peilong Lu, Xin Li, Houra Merrikh, Zihe Rao, Wenqing Xu

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. O-acyltransferase genes involved in the production of volatile sex pheromones inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Structural Insights into theBiomolecules · 2025
    Article
  8. Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025
    Review
  9. Structural basis for Porcupine inhibition.Communications chemistry · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dan MaDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Zhizhi WangDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Christopher N MerrikhDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Kevin S LangDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Peilong LuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Xin LiDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Houra MerrikhDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Zihe RaoCollege of Life Sciences, State Key Laboratory of Medicinal Chemistry Laboratory, Nankai University, Tianjin, China.
Wenqing XuDepartment of Biological Structure, University of Washington, Seattle, WA, USA. wxu@uw.edu.
University of Washington · USChinese Academy of Sciences · CNTsinghua University · CN

Funding

INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
Targeted Gene Evolution via Replication-Transcription ConflictsDP2GM110773 · NIGMS · UNIVERSITY OF WASHINGTON · PI MERRIKH, HOURA · 2013 to 2013
$2.2M
Structural analysis of membrane-bound O-acyltransferasesR01GM127316 · NIGMS · UNIVERSITY OF WASHINGTON · PI STENKAMP, RONALD E · 2018 to 2019
$327k
NIAID NIH HHS T32 AI055396NIGMS NIH HHS DP2 GM110773NIGMS NIH HHS R01 GM127316
6 · The paper itself

Abstract

Membrane-bound O-acyltransferases (MBOATs) are a superfamily of integral transmembrane enzymes that are found in all kingdoms of life

Indexed as

AcyltransferasesAmino Acid SequenceAnimalsBacillus subtilisBacterial ProteinsBinding SitesBiocatalysisCarrier ProteinsCell WallConserved SequenceCrystallography, X-RayHistidineLipid BilayersLipopolysaccharidesMembrane Transport ProteinsModels, MolecularAcyltransferasesBacterial ProteinsCarrier ProteinsD-alanyl carrier protein, bacteriaDltB protein, StaphylococcusHistidineLipid BilayersLipopolysaccharideslipoteichoic acidMembrane Transport ProteinsTeichoic Acids

Identifiers

PMID30283133
PMCPMC6529733
OpenAlexW2895478883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.