ArticleScientific reports2018
Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Calorie-restricted oat diet is associated with zonulin and short-chain fatty acid response in metabolic syndrome: a randomized controlled trial.Gut microbes · 2026Trial
- The Effects of Caloric Restriction and Clinical Psychological Intervention on the Interplay of Gut Microbial Composition and Stress in Women.Nutrients · 2024Trial
- Diet- and sex-related changes of gut microbiota composition and functional profiles after 4 months of weight loss intervention.European journal of nutrition · 2021Trial
- Christensenella minuta DSM 22607 and Food Restriction Manage Age-Related Disorders In Vivo.Probiotics and antimicrobial proteins · 2026Article
- Article
- Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome.Scientific reports · 2026Article
- Consumption of traditional Sardinian fermented milk promotes changes in the rat gut microbiota composition and functions.BMC microbiology · 2025Article
- Dietary Restrictions and Cancer Prevention: State of the Art.Nutrients · 2025Review
- The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer.International journal of molecular sciences · 2024Review
- Metaproteomic Analysis of Fecal Samples from Human Subjects and Rodent Models.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Review
- Plasma Concentrations of Short-Chain Fatty Acids in Active and Recovered Anorexia Nervosa.Nutrients · 2022Article
- Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization.Cell reports · 2022Article
- Excess Growth Hormone Alters the Male Mouse Gut Microbiome in an Age-dependent Manner.Endocrinology · 2022Article
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Microbiota and body weight control: Weight watchers within?Molecular metabolism · 2022Review
- Effects of dietary restriction on gut microbiota and CNS autoimmunity.Clinical immunology (Orlando, Fla.) · 2022Review
- The ups and downs of caloric restriction and fasting: from molecular effects to clinical application.EMBO molecular medicine · 2022Review
- Article
- The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets.Frontiers in nutrition · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the short- and long-term effects of CR on the rat GM using a metaproteogenomic approach. We show that a switch from ad libitum (AL) low fat diet to CR in young rats is able to induce rapid and deep changes in their GM metaproteomic profile, related to a reduction of the Firmicutes/Bacteroidetes ratio and an expansion of lactobacilli. Specifically, we observed a significant change in the expression of the microbial enzymes responsible for short-chain fatty acid biosynthesis, with CR boosting propionogenesis and limiting butyrogenesis and acetogenesis. Furthermore, these CR-induced effects were maintained up to adulthood and started to be reversed after a short-term diet change. We also found that CR alters the abundance of an array of host proteins released in stool, mainly related to epithelial barrier integrity and inflammation. Hence, our results provide thorough information about CR-induced modifications to GM and host functional activity, and might constitute the basis for novel GM-based approaches aimed at monitoring the effectiveness of dietary interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.