Evidence map›Paper›PMID 30283042›Full record

ArticleScientific reports2018

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease.

Lisa M McGinley, Osama N Kashlan, Elizabeth S Bruno, Kevin S Chen, John M Hayes, Samy R Kashlan, Julia Raykin, Karl Johe, Geoffrey G Murphy, Eva L Feldman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Pooled it
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  10. Water extract ofMolecular medicine reports · 2025
    Article
  11. Metabolic stress and age drive inflammation and cognitive decline in mice and humans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Review
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  14. Review
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  16. Article
  17. Proposed Mechanisms of Cell Therapy for Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lisa M McGinleyDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Osama N KashlanDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Elizabeth S BrunoDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Kevin S ChenDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
John M HayesDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Samy R KashlanDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Julia RaykinDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Karl JoheNeuralstem, Inc, Germantown, MD, USA.
Geoffrey G MurphyDepartment of Molecular & Integrative Physiology, Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA. efeldman@umich.edu.
University of Michigan–Ann Arbor · USGeorgia Institute of Technology · USNeural Signals (United States) · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0M
Testing the Calcium Hypothesis of Age-related Cognitive DeclineR01AG052934 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, GEOFFREY G · 2016 to 2020
$2.1M
UM Clinical Neuroscientist Training ProgramR25NS089450 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2023
$1.3M
NIA NIH HHS R01 AG052934NIDDK NIH HHS P30 DK020572NINDS NIH HHS R25 NS089450NINDS NIH HHS T32 NS007222
6 · The paper itself

Abstract

Stem cell transplantation offers a potentially transformative approach to treating neurodegenerative disorders. The safety of cellular therapies is established in multiple clinical trials, including our own in amyotrophic lateral sclerosis. To initiate similar trials in Alzheimer's disease, efficacious cell lines must be identified. Here, we completed a preclinical proof-of-concept study in the APP/PS1 murine model of Alzheimer's disease. Human neural stem cell transplantation targeted to the fimbria fornix significantly improved cognition in two hippocampal-dependent memory tasks at 4 and 16 weeks post-transplantation. While levels of synapse-related proteins and cholinergic neurons were unaffected, amyloid plaque load was significantly reduced in stem cell transplanted mice and associated with increased recruitment of activated microglia. In vitro, these same neural stem cells induced microglial activation and amyloid phagocytosis, suggesting an immunomodulatory capacity. Although long-term transplantation resulted in significant functional and pathological improvements in APP/PS1 mice, stem cells were not identified by immunohistochemistry or PCR at the study endpoint. These data suggest integration into native tissue or the idea that transient engraftment may be adequate for therapeutic efficacy, reducing the need for continued immunosuppression. Overall, our results support further preclinical development of human neural stem cells as a safe and effective therapy for Alzheimer's disease.

Indexed as

Stem Cell TransplantationAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCholinergic NeuronsDisease Models, AnimalHippocampusHumansImmunosuppression TherapyMemoryMiceMice, TransgenicMicrogliaNeural Stem CellsPhagocytosisSynapsesAmyloid beta-Peptides

Identifiers

PMID30283042
PMCPMC6170460
OpenAlexW2893177846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.