ReviewMolecular psychiatry2019
Intergenerational transmission of depression: clinical observations and molecular mechanisms.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Hypothalamic-pituitary-adrenal axis functioning in offspring of parents with a major affective disorder: a meta-analytic review.European child & adolescent psychiatry · 2025Pooled it
- From placenta to the foetus: a systematic review of in vitro models of stress- and inflammation-induced depression in pregnancy.Molecular psychiatry · 2025Pooled it
- Psychopathology in the Offspring of Indigenous Parents with Mental Health Challenges: A Systematic Review: Psychopathologie des descendants de parents autochtones ayant des problèmes de santé mentale: Une revue systématique.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Pooled it
- Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review.Nutrients · 2021Pooled it
- Positive and negative maternal mental health demonstrate distinct pathways to childhood depression.Psychological medicine · 2026Article
- Intergenerational associations of depression and anxiety among adult mother-daughter dyads in China.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Intergenerational transmission of maternal and adolescent depressive symptoms: cross-sectional and cross-lagged panel network analysis.Child and adolescent psychiatry and mental health · 2026Article
- A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression.Frontiers in psychiatry · 2026Review
- Infants' empathic concern responses moderate the association between maternal and child depressive symptoms.Scientific reports · 2025Article
- Pathways of intergenerational transmission of depression: The role of the Fast Track intervention.Development and psychopathology · 2025Article
- The Interplay between Maternal Depression and ADHD Symptoms in Predicting Emotional and Attentional Functioning in Toddlerhood.Research on child and adolescent psychopathology · 2025Article
- Exploring the impact of maternal early life adversity on interoceptive sensibility in pregnancy: implications for prenatal depression.Archives of women's mental health · 2025Article
- Parent-adolescent intergenerational transmission of distress: the roles of family climate, adolescents' self-compassion and mindfulness.Frontiers in psychology · 2025Article
- Interoception in pregnancy: Implications for peripartum depression.Neuroscience and biobehavioral reviews · 2024Review
- The importance of timing of socioeconomic disadvantage throughout development for depressive symptoms and brain structure.Developmental cognitive neuroscience · 2024Article
- Polycyclic aromatic hydrocarbon exposure effects on trajectories of maternal and adolescent mental health.Child and adolescent psychiatry and mental health · 2024Article
- Network-Assisted Mediation Analysis with High-Dimensional Neuroimaging Mediators.Proceedings of machine learning research · 2024Article
- The Impact of Maternal Interpersonal Violent Trauma and Related Psychopathology on Child Outcomes and Intergenerational Transmission.Current psychiatry reports · 2024Review
- Prenatal and postnatal influences on behavioral development in a mouse model of preconceptional stress.Neurobiology of stress · 2024Article
- The cost-utility of an intervention for children and adolescents with a parent having a mental illness in the framework of the German health and social care system: a health economic evaluation of a randomized controlled trial.Child and adolescent psychiatry and mental health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Maternal mental illness can have a devastating effect during the perinatal period, and has a profound impact on the care that the baby receives and on the relationships that the baby forms. This review summarises clinical evidence showing the effects of perinatal depression on offspring physical and behavioural development, and on the transmission of psychopathology between generations. We then evaluate a number of factors which influence this relationship, such as genetic factors, the use of psychotropic medications during pregnancy, the timing within the perinatal period, the sex of the foetus, and exposure to maltreatment in childhood. Finally, we examine recent findings regarding the molecular mechanisms underpinning these clinical observations, and identify relevant epigenetic and biomarker changes in the glucocorticoid, oxytocin, oestrogen and immune systems, as key biological mediators of these clinical findings. By understanding these molecular mechanisms in more detail, we will be able to improve outcomes for both mothers and their offspring for generations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.