Evidence map›Paper›PMID 30283025›Full record

ArticleScientific reports2018

Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms.

Trevor Beaudoin, Tracy A Stone, Miroslawa Glibowicka, Christina Adams, Yvonne Yau, Saumel Ahmadi, Christine E Bear, Hartmut Grasemann, Valerie Waters, Charles M Deber

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Lower respiratory tract microbiota characteristics in patients withFrontiers in cellular and infection microbiology · 2026
    Article
  2. From computational screening toFrontiers in microbiology · 2026
    Article
  3. Article
  4. Article
  5. Effect of L-arginine on cystic fibrosisAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. In Silico and In vitro Evaluations of the Antibacterial Activities of HIV-1 Nef Peptides againstInternational journal of molecular and cellular medicine · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Antimicrobial Peptides against Multidrug-ResistantJournal of medicinal chemistry · 2022
    Article
  15. Tryptone in Growth Media EnhancesMicroorganisms · 2022
    Article
  16. Treatment ofFrontiers in microbiology · 2022
    Review
  17. Article
  18. Frontiers in microbiology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Trevor BeaudoinDivision of Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Tracy A StoneDivision of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Miroslawa GlibowickaDivision of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Christina AdamsDivision of Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Yvonne YauDivision of Microbiology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.
Saumel AhmadiDivision of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Christine E BearDivision of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Hartmut GrasemannDivision of Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Valerie WatersDivision of Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
Charles M DeberDivision of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada. deber@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing recognition of biofilms in human disease, the development of novel antimicrobial therapies is of critical importance. For example, in patients with cystic fibrosis (CF), the acquisition of host-adapted, chronic Pseudomonas aeruginosa infection is associated with a decline in lung function and increased mortality. Our objective was to test the in vitro efficacy of a membrane-active antimicrobial peptide we designed, termed 6K-F17 (sequence: KKKKKK-AAFAAWAAFAA-NH

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesBiofilmsEpithelial CellsErythrocytesHumansMicroscopy, ConfocalPseudomonas aeruginosaPseudomonas InfectionsSputumTobramycinAnti-Infective AgentsAntimicrobial Cationic PeptidesTobramycin

Identifiers

PMID30283025
PMCPMC6170476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.