ArticleScientific reports2018
Surface-modified three-dimensional graphene nanosheets as a stationary phase for chromatographic separation of chiral drugs.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 32 citations in OpenAlex.
- The rise of chiral carbon nanomaterials: From chirality-governed mechanisms to future environmental applications.iScience · 2026Review
- Surface modified nanoparticles and their applications for enantioselective detection, analysis, and separation of various chiral compounds.RSC advances · 2023Review
- A Molecular Shape Recognitive HPLC Stationary Phase Based on a Highly Ordered Amphiphilic Glutamide Molecular Gel.Nanomaterials (Basel, Switzerland) · 2021Article
- Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Covalent Epitope Decoration of Carbon Electrodes using Solid Phase Peptide Synthesis.Scientific reports · 2019Article
- Enantiomeric Recognition and Separation by Chiral Nanoparticles.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to conventional silica-based alternatives. In our work, we demonstrate a new variant of carbon-based stationary phases for liquid chromatography, specifically developed for chiral separation. Mesoporous three-dimensional graphene nanosheets (3D GNS), functionalized with tetracyanoethylene oxide (TCNEO) and (S)-(+)-2-pyrrolidinemethanol, demonstrate pharmaceutical-grade chiral separation of model ibuprofen and thalidomide racemic mixtures when used as Chiral Stationary Phases (CSPs), with performance parameters comparable to currently commercially available CSPs. Simple covalent attachment of functionalization groups to the surface of mesoporous three-dimensional graphene nanosheets makes these carbon-based CSPs chemically stable and up to an order of magnitude less expensive than standard silica-based analogues.
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Registered trials
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