Evidence map›Paper›PMID 30282907›Full record

ArticleViruses2018

Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation.

Sarah Zobel, Mechthild Lorenz, Giada Frascaroli, Janik Böhnke, Nicole C Bilz, Megan L Stanifer, Steeve Boulant, Sandra Bergs, Uwe G Liebert, Claudia Claus

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Dissecting Rubella Placental Infection in an In Vitro Trophoblast Model.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sarah ZobelInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. zobel.sarah@icloud.com.
Mechthild LorenzInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. Mechthild.Lorenz@medizin.uni-leipzig.de.
Giada FrascaroliLeibniz Institute for Experimental Virology, Heinrich Pette Institute, 20251 Hamburg, Germany. giada.frascaroli@leibniz-hpi.de.
Janik BöhnkeInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. janik.boehnke@gmail.com.
Nicole C BilzInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. Christin.Emmrich@medizin.uni-leipzig.de.
Megan L StaniferSchaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University Hospital, 69120 Heidelberg, Germany. m.stanifer@dkfz-heidelberg.de.
Steeve BoulantSchaller Research Group at CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University Hospital, 69120 Heidelberg, Germany. s.boulant@Dkfz-Heidelberg.de.ORCID 0000-0001-8614-4993
Sandra BergsInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. Sandra.Bergs@medizin.uni-leipzig.de.
Uwe G LiebertInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. liebert@medizin.uni-leipzig.de.ORCID 0000-0002-5129-0875
Claudia ClausInstitute of Virology, University of Leipzig, 04103 Leipzig, Germany. claudia.claus@medizin.uni-leipzig.de.ORCID 0000-0003-4962-6568
Leipzig University · DEGerman Cancer Research Center · DEHeidelberg University · DELeibniz Institute of Virology (LIV) · DE

Funding

Deutsche Forschungsgemeinschaft CL 459/3-1
6 · The paper itself

Abstract

Rubella virus (RV) infection impacts cellular metabolic activity in a complex manner with strain-specific nutritional requirements. Here we addressed whether this differential metabolic influence was associated with differences in oxidative stress induction and subsequently with innate immune response activation. The low passaged clinical isolates of RV examined in this study induced oxidative stress as validated through generation of the reactive oxygen species (ROS) cytoplasmic hydrogen peroxide and mitochondrial superoxide. The addition of the cytoplasmic and mitochondrial ROS scavengers

Indexed as

Oxidative StressAcetylcysteineAnimalsApoptosisCells, CulturedChlorocebus aethiopsEpithelial CellsHumansHydrogen PeroxideImmunity, InnateInterferon-betaInterferonsMacrophagesMitochondriaReactive Oxygen SpeciesRubellaAcetylcysteineHydrogen PeroxideInterferon-betaInterferonsReactive Oxygen SpeciesSuperoxidesapoptosiscaspase 3/7interferon-stimulated geneISG15macrophageMitoTEMPON-acetyl-l-cysteineviperin

Identifiers

PMID30282907
PMCPMC6213305
OpenAlexW2895729032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.