ArticleJCI insight2018
Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics.
Article in JCI insight, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Extended local anesthesia enabled by flavonoid permeation enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Experimental biofilm models for pharmacokinetic and pharmacodynamic investigations: bridging in vitro, ex vivo and in vivo systems.The Journal of antimicrobial chemotherapy · 2026Review
- A Pseudo-Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics.Advanced healthcare materials · 2024Article
- Biomedical application of materials for external auditory canal: History, challenges, and clinical prospects.Bioactive materials · 2024Review
- In vivo biodistribution and ototoxicity assessment of cationic liposomal-ceftriaxone via noninvasive trans-tympanic delivery in chinchilla models: Implications for otitis media therapy.International journal of pediatric otorhinolaryngology · 2024Article
- Research progress related to thermosensitive hydrogel dressings in wound healing: a review.Nanoscale advances · 2023Review
- Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear.Frontiers in pharmacology · 2023Review
- On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media.Nano today · 2022Article
- An In Vitro Model for Characterization of Drug Permeability across the Tympanic Membrane.Pharmaceuticals (Basel, Switzerland) · 2022Article
- An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Ex vivo transtympanic permeation of the liposome encapsulated S. pneumoniae endolysin MSlys.International journal of pharmaceutics · 2022Article
- Impact of small molecule and reverse poloxamer addition on the micellization and gelation mechanisms of poloxamer hydrogels.Colloids and surfaces. A, Physicochemical and engineering aspects · 2022Article
- Article
- Inner Ear Drug Delivery for Sensorineural Hearing Loss: Current Challenges and Opportunities.Frontiers in neuroscience · 2022Review
- Drug Delivery across Barriers to the Middle and Inner Ear.Advanced functional materials · 2021Article
- Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications.Gels (Basel, Switzerland) · 2021Review
- Permeation of polyethylene glycols across the tympanic membrane.Giant (Oxford, England) · 2021Article
- From Evidence to Clinical Guidelines in Antibiotic Treatment in Acute Otitis Media in Children.Antibiotics (Basel, Switzerland) · 2021Review
- Novel Antimicrobial Treatment Strategy Based on Drug Delivery Systems for Acute Otitis Media.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Otits media (OM) is the most frequent indication for antimicrobial prescription to US children. Streptococcus pneumoniae (S. pneumoniae) remains one of the most common pathogens causing OM. Successful eradication of S. pneumoniae in the middle ear can be achieved by adhering to a 7-10 day regimen of oral antibiotics. However, oral drug administration is challenging for parents. Lack of adherence has been associated with treatment failure or early relapse. To overcome this challenge, we used a noninvasive formulation to achieve high transtympanic antibiotic flux and cured S. pneumoniae OM in chinchillas. The formulation consists of a thermosensitive in situ gelling hydrogel, chemical permeation enhancers, and an antibiotic. The direct transport of drugs into the middle ear produced high concentrations of ciprofloxacin (in the range of hundreds of micrograms per milliliter) within the first 24 hours of administration. Drug concentrations above the minimum inhibitory concentration (MIC) for S. pneumoniae were sustained throughout the 7-day treatment. S. pneumoniae OM in a chinchilla model was successfully eradicated, without causing tissue toxicity. Transtympanic delivery minimized systemic drug exposure, as evidenced by undetectable levels in blood, measured by high-performance liquid chromatography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.