ArticleBlood2018
Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.
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Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Platelet activation and short-term rifaximin therapy in decompensated cirrhosis: a pilot randomized controlled study.Internal and emergency medicine · 2026Trial
- Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications.Cancer metastasis reviews · 2026Review
- Beyond Hemostasis: Platelets' Multifaceted Functions in Immune Responses.Life (Basel, Switzerland) · 2026Review
- Endogenous "Time Bomb" - Mislocalized Phospholipase A2 as a Critical Mediator of Ultra-Rapid Mortality in Sepsis and Acute Lung Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Persistent Chronic Thrombo-Inflammation in Anti-Glomerular Basement Membrane Disease Despite Immune Complex Removal.Kidney international reports · 2025Article
- Targeting Lung Damage: Amniotic Mesenchymal Stem Cells Mitigate Lipopolysaccharide-Induced Acute Lung Injury via Multiple Signaling Pathways.International journal of molecular sciences · 2025Article
- High Levels of Triggering Receptor Expressed in Myeloid Cells-Like Transcript-1 Positive, but Not Glycoprotein 1b+, Microparticles Are Associated With Poor Outcomes in Acute Respiratory Distress Syndrome.Critical care explorations · 2024Article
- A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders.Nature cardiovascular research · 2024Article
- Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- The Characterization and Evaluation of the Soluble Triggering Receptor Expressed on Myeloid Cells-like Transcript-1 in Stable Coronary Artery Disease.International journal of molecular sciences · 2023Article
- The biology of TREM receptors.Nature reviews. Immunology · 2023Review
- Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease-A Translational Perspective.International journal of molecular sciences · 2023Review
- Whole Blood Transfusion for Severe Malarial Anemia in a High Plasmodium falciparum Transmission Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Platelet Count in Patients with SARS-CoV-2 Infection: A Prognostic Factor in COVID-19.Journal of clinical medicine · 2022Article
- Characterization of Platelet Biologic Markers in the Early Pathogenesis of Postoperative Acute Respiratory Distress Syndrome.Critical care explorations · 2022Article
- PlateletCells · 2022Review
- Platelet in thrombo-inflammation: Unraveling new therapeutic targets.Frontiers in immunology · 2022Review
- The enigmatic nature of the triggering receptor expressed in myeloid cells -1 (TLT- 1).Platelets · 2021Review
- DIA proteomics analysis through serum profiles reveals the significant proteins as candidate biomarkers in women with PCOS.BMC medical genomics · 2021Article
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Authors and funding
19 authors at 5 institutions in 2 countries.
Jessica Morales-OrtízDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Victoria DealDivision of Natural Sciences, Maryville College, Maryville, TN.
Fiorella ReyesDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Gerónimo Maldonado-MartínezRetroviral Research Center, Universidad Central del Caribe, Bayamón, Puerto Rico.
Nahomy LedesmaDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Franklin StabackDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Cheyanne CroftDivision of Natural Sciences, Maryville College, Maryville, TN.
Amanda PachecoDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Humberto Ortiz-ZuazagaDepartment of Computer Science, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
C Christian YostDepartment of Pediatrics/Neonatology and Molecular Medicine Program and.
Jesse W RowleyDepartment of Internal Medicine and Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT.
Bismark MaderaDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.
Alex St JohnBloodworks Northwest Research Institute, Seattle, WA; and.
Junmei ChenBloodworks Northwest Research Institute, Seattle, WA; and.
Jose LopezBloodworks Northwest Research Institute, Seattle, WA; and.
Matthew T RondinaDepartment of Internal Medicine and Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT.
Robert HunterRetroviral Research Center, Universidad Central del Caribe, Bayamón, Puerto Rico.
Angelia GibsonDivision of Natural Sciences, Maryville College, Maryville, TN.
A Valance WashingtonDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, Puerto Rico.ORCID 0000-0002-3458-1822
University of Puerto Rico at Río Piedras · PRBloodworks Northwest · USMaryville College · USCentral University of the Caribbean · PRUniversity of Utah · US
Funding
SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SURANGANIE DHARMAWARDHANE · 2012 to 2026
$52.9MTECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., WOJNA, VALERIE · 2012 to 2018
$23.2MThe Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6MTranslational Research Skills Development CoreU54HL112311 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S, ZIMMERMAN, GUY A. · 2012 to 2016
$12.9MUNIVERSIDAD CENTRAL DEL CARIBE BIOMEDICAL RESEARCH CENTERSG12MD007583 · NIMHD · UNIVERSIDAD CENTRAL DEL CARIBE · PI FERNANDEZ, DIANA MARIA · 2012 to 2016
$8.4MThe Effects of ART on Platelets and HIV-Associated ThrombosisR01HL126547 · NHLBI · UNIVERSITY OF UTAH · PI PLANELLES, VICENTE, RONDINA, MATTHEW THOMAS · 2014 to 2017
$3.0MTranslation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)R01HL090933 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI WASHINGTON, A. VALANCE · 2011 to 2022
$2.9MThe Platelet Metabolome in ObesityK01GM103806 · NIGMS · UNIVERSITY OF UTAH · PI ROWLEY, JESSE · 2012 to 2016
$802kDefining the Role of TREM-Like Transcript-1 in Platelet AggregationSC2GM081237 · NIGMS · UNIVERSIDAD CENTRAL DEL CARIBE · PI WASHINGTON, A. VALANCE · 2007 to 2007
$103kThe Evaluation of TLT-1 as treatment for ALI/ARDSF31HL136183 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI MORALES-ORTIZ, JESSICA · 2017 to 2018
$49kNHLBI NIH HHS F31 HL136183NHLBI NIH HHS R01 HL090933NHLBI NIH HHS R01 HL126547NHLBI NIH HHS U54 HL112311NIGMS NIH HHS K01 GM103806NIGMS NIH HHS P20 GM103475NIGMS NIH HHS P20 GM103642NIGMS NIH HHS SC2 GM081237NIMHD NIH HHS G12 MD007583NIMHD NIH HHS U54 MD007587
Abstract
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (
Indexed as
Acute Lung InjuryAnimalsBlood PlateletsDisease Models, AnimalHumansMiceMice, KnockoutNeutrophil InfiltrationNeutrophilsPredictive Value of TestsReceptors, ImmunologicRespiratory Distress SyndromeTransendothelial and Transepithelial MigrationReceptors, ImmunologicTREML1 protein, humanTreml1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.