Evidence map›Paper›PMID 30282755›Full record

ArticlemSphere2018

A Computational Modeling Approach Predicts Interaction of the Antifungal Protein AFP from

Tillmann Utesch, Alejandra de Miguel Catalina, Caspar Schattenberg, Norman Paege, Peter Schmieder, Eberhard Krause, Yinglong Miao, J Andrew McCammon, Vera Meyer, Sascha Jung and 1 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tillmann UteschInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.
Alejandra de Miguel CatalinaInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.
Caspar SchattenbergInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.
Norman PaegeInstitute of Biotechnology, Department Applied and Molecular Microbiology, Technische Universität Berlin, Berlin, Germany.
Peter SchmiederLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Eberhard KrauseLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Yinglong MiaoCenter for Computational Biology, University of Kansas, Lawrence, Kansas, USA.
J Andrew McCammonDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, California, USA.
Vera MeyerInstitute of Biotechnology, Department Applied and Molecular Microbiology, Technische Universität Berlin, Berlin, Germany.
Sascha JungInstitute of Biotechnology, Department Applied and Molecular Microbiology, Technische Universität Berlin, Berlin, Germany.
Maria Andrea MroginskiInstitut für Chemie, Technische Universität Berlin, Berlin, Germany andrea.mroginski@tu-berlin.de.ORCID 0000-0002-7497-5631
Technische Universität Berlin · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DEUniversity of California San Diego · USUniversity of Kansas · US

Funding

National Biomedical Computation Resource - Competitive Revision SupplementP41GM103426 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2012 to 2019
$14.0M
THEORY OF BIOMOLECULAR DIFFUSIONR01GM031749 · NIGMS · UNIVERSITY OF HOUSTON · PI HUBER, GARY ALEXANDER, MCCAMMON, JAMES ANDREW · 1985 to 2022
$7.8M
NIGMS NIH HHS P41 GM103426NIGMS NIH HHS R01 GM031749
6 · The paper itself

Abstract

Fungal pathogens kill more people per year globally than malaria or tuberculosis and threaten international food security through crop destruction. New sophisticated strategies to inhibit fungal growth are thus urgently needed. Among the potential candidate molecules that strongly inhibit fungal spore germination are small cationic, cysteine-stabilized proteins of the AFP family secreted by a group of filamentous Ascomycetes. Its founding member, AFP from

Indexed as

Antifungal AgentsAspergillusAspergillus nigerCell Membrane PermeabilityComputer SimulationFungal ProteinsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular Dynamics SimulationAntifungal AgentsFungal ProteinsAFPantifungal peptidesfungimembranesmodelingmolecular dynamicsnuclear magnetic resonance

Identifiers

PMID30282755
PMCPMC6170789
OpenAlexW2895633357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.