ArticleProceedings of the National Academy of Sciences of the United States of America2018
Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus regulate male social hierarchies.PLoS biology · 2026Article
- 7,8-DHF Modulates Aggressive Behavior inAnimals : an open access journal from MDPI · 2025Article
- Perturbations in the microbiota-gut-brain axis shaped by social status loss.Communications biology · 2025Article
- Astroglia's role in synchronized spontaneous neuronal activity: from physiology to pathology.Frontiers in cellular neuroscience · 2025Review
- Mesocorticolimbic circuit mechanisms of social dominance behavior.Experimental & molecular medicine · 2024Review
- Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance.Nature neuroscience · 2023Article
- Excision of mesenteric lymph nodes alters gut microbiota and impairs social dominance in adult mice.Brain and behavior · 2023Article
- Aggression in Group-Housed Male Mice: A Systematic Review.Animals : an open access journal from MDPI · 2022Review
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Light control of RTK activity: from technology development to translational research.Chemical science · 2020Review
- BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia, Promoting Survival of GABAergic Neurons.Neuroscience bulletin · 2020Article
- A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb.Cell research · 2020Article
- Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-SpecificFrontiers in molecular neuroscience · 2020Article
- Pandora's Box.BJPsych international · 2019Article
- Exercise modulation of BDNF/TrkB signaling in Parkinson's disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The tight balance between synaptic excitation and inhibition (E/I) within neocortical circuits in the mammalian brain is important for complex behavior. Many loss-of-function studies have demonstrated that brain-derived neurotrophic factor (BDNF) and its cognate receptor tropomyosin receptor kinase B (TrkB) are essential for the development of inhibitory GABAergic neurons. However, behavioral consequences of impaired BDNF/TrkB signaling in GABAergic neurons remain unclear, largely due to confounding motor function deficits observed in previous animal models. In this study, we generated conditional knockout mice (TrkB cKO) in which TrkB was ablated from a majority of corticolimbic GABAergic interneurons postnatally. These mice showed intact motor coordination and movement, but exhibited enhanced dominance over other mice in a group-housed setting. In addition, immature fast-spiking GABAergic neurons of TrkB cKO mice resulted in an E/I imbalance in layer 5 microcircuits within the medial prefrontal cortex (mPFC), a key region regulating social dominance. Restoring the E/I imbalance via optogenetic modulation in the mPFC of TrkB cKO mice normalized their social dominance behavior. Taken together, our results provide strong evidence for a role of BDNF/TrkB signaling in inhibitory synaptic modulation and social dominance behavior in mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.