ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Nucleus Reuniens Is Required for Encoding and Retrieving Precise, Hippocampal-Dependent Contextual Fear Memories in Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Article
- Prefrontal-thalamic goal states organize spatially aligned hippocampal maps.Nature communications · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Review
- An amygdala-cortical circuit for encoding generalized fear memories.Molecular psychiatry · 2026Article
- Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.Molecular psychiatry · 2025Article
- Acquisition of trace fear conditioning without functional nucleus reuniens did not require dorsal or ventral hippocampus NMDA receptor activation in male Long-Evans rats.The international journal of neuropsychopharmacology · 2025Article
- Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans.Communications biology · 2025Article
- Article
- Activation patterns in male and female forebrain areas during habituation to food and context novelty.Brain structure & function · 2025Article
- A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.bioRxiv : the preprint server for biology · 2025Article
- The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep.eLife · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents.Translational psychiatry · 2025Article
- Nucleus reuniens: Modulating emotional overgeneralization in peri-adolescents with anxiety.Cognitive, affective & behavioral neuroscience · 2025Article
- The Emerging Role of Brain Mitochondria in Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits.Communications biology · 2024Article
- Mystery of the memory engram: History, current knowledge, and unanswered questions.Neuroscience and biobehavioral reviews · 2024Review
2 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The nucleus reuniens (RE) is a ventral midline thalamic nucleus that interconnects the medial prefrontal cortex (mPFC) and hippocampus (HPC). Considerable data indicate that HPC-mPFC circuits are involved in contextual and spatial memory; however, it is not clear whether the RE mediates the acquisition or retrieval of these memories. To examine this question, we inactivated the RE with muscimol before either the acquisition or retrieval of pavlovian fear conditioning in rats; freezing served as the index of fear. We found that RE inactivation before conditioning impaired the acquisition of contextual freezing, whereas inactivation of the RE before retrieval testing increased the generalization of freezing to a novel context; inactivation of the RE did not affect either the acquisition or expression of auditory fear conditioning. Interestingly, contextual conditioning impairments were absent when retrieval testing was also conducted after RE inactivation. Contextual memories acquired under RE inactivation were hippocampal independent, insofar as contextual freezing in rats conditioned under RE inactivation was insensitive to intrahippocampal infusions of the NMDA receptor antagonist aminophosphonovalerate. Together, these data reveal that the RE supports hippocampal-dependent encoding of precise contextual memories that allow discrimination of dangerous contexts from safe contexts. When the RE is inactive, however, alternate neural systems acquire an impoverished contextual memory that is expressed only when the RE is off-line.
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