Trial reportScience translational medicine2018
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.
Registry-linked trialAbstract readClinical Trial
In one paragraph
Trial report in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05186623 (Establishment of Prediction Model of Biologics and Small Molecular Agent for Patients With Ulcerative Colitis Using Longitudinal Data), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishment of Prediction Model of Biologics and Small Molecular Agent for Patients With Ulcerative Colitis Using Longitudinal Data
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Noninfectious Pulmonary Complications Associated With Anti-Integrin Therapy: A Case Report and Systematic Review of the Literature.Inflammatory bowel diseases · 2022Pooled it
- Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size.JCI insight · 2024Trial
- Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species.PLoS pathogens · 2022Trial
- HIV Reservoirs Across Multiple Tissues: From Heterogeneous Mechanisms to Therapeutic Targeting.Microorganisms · 2026Review
- IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells.PLoS pathogens · 2026Article
- Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- A new era in CAR-NK cell therapy: from technological innovations to clinical applications.World journal of pediatrics : WJP · 2026Review
- Integrin α4β7 as a predictor of HIV acquisition: one thread in a complex tapestry.The Journal of clinical investigation · 2025Article
- HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies.Frontiers in immunology · 2025Review
- Gastrointestinal germinal center B cell depletion and reduction in IgAScience immunology · 2024Article
- Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.Inflammatory bowel diseases · 2024Article
- Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease.Mucosal immunology · 2023Review
- Human intestinal B cells in inflammatory diseases.Nature reviews. Gastroenterology & hepatology · 2023Review
- Differences in Whole-Blood Transcriptional Profiles in Inflammatory Bowel Disease Patients Responding to Vedolizumab Compared with Non-Responders.International journal of molecular sciences · 2023Article
- MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells.PLoS pathogens · 2023Article
- Review
- α4β7 expression guides B cells to front lines of defense in the gut.Mucosal immunology · 2022Article
- Harnessing murine models of Crohn's disease ileitis to advance concepts of pathophysiology and treatment.Mucosal immunology · 2022Review
- Early treatment with anti-αFrontiers in immunology · 2022Article
- The Impact of Vedolizumab on COVID-19 Outcomes Among Adult IBD Patients in the SECURE-IBD Registry.Journal of Crohn's & colitis · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 7 institutions in 2 countries.
Mathieu UzzanImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-7761-2879
Minami TokuyamaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-6488-9687
Adam K RosensteinImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Costin TomescuWistar Institute, Philadelphia, PA 19104, USA.
Ivo N SahBandarDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0001-8375-8463
Huaibin M KoDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-1062-2383
Louise LeyreCentre de recherche du Centre hospitalier de l'Université de Montréal and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Québec H2X 0A9, Canada.
Anupa ChokolaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4225-7640
Emma Kaplan-LewisDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gabriela RodriguezDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Akihiro SekiImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Michael J CorleyDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Judith AbergDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8162-0284
Annalena La PorteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eun-Young ParkDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0001-6176-3771
Hideki UenoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-7747-0738
Ioannis OikonomouDivision of Gastroenterology, Rush University, Chicago, IL 60612, USA.
Itai DoronGastroenterology and Hepatology Divison, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-6855-2977
Iliyan D IlievGastroenterology and Hepatology Divison, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-0884-9749
Benjamin K ChenImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-5404-1997
Jennifer LuiImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Timothy W SchackerDepartment of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2451-9937
Glaucia C FurtadoImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8489-5697
Sergio A LiraImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jean-Frederic ColombelDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Amir HorowitzImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4602-1440
Jean K LimDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-4572-6417
Nicolas ChomontCentre de recherche du Centre hospitalier de l'Université de Montréal and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Québec H2X 0A9, Canada.ORCID 0000-0001-9747-5018
Adeeb H RahmanHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-8620-3161
Luis J MontanerWistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0001-5799-6759
Lishomwa C NdhlovuDepartment of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Saurabh MehandruImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. saurabh.mehandru@mssm.edu.ORCID 0000-0001-9781-2969
Icahn School of Medicine at Mount Sinai · USUniversity of Hawaiʻi at Mānoa · USCentre Hospitalier de l’Université de Montréal · CACornell University · USThe Wistar Institute · USRush University · USUniversity of Minnesota Medical Center · US
Funding
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6MThe Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MTRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5MRESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1MMechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1MTRAINING IN PHARMACOLOGY OF DRUGS OF ABUSET32DA007135 · NIDA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI DEVI, LAKSHMI A · 1985 to 2018
$4.9MCommensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2MMolecular pathogenesis of intestinal serrated polypsR01CA161373 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2011 to 2020
$3.7MCell migration and virological synapse formation in parenteral HIV transmissionR01DA041765 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN, BENJAMIN K · 2016 to 2020
$2.1MThe impact of HIV-1 infection and its treatment on gastrointestinal B cellsR01DK112296 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MEHANDRU, SAURABH · 2017 to 2021
$2.0MThe role of epigenetic transcriptional memory in monocyte-macrophage cells and cardiovascular disease riskK01HL140271 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CORLEY, MICHAEL JAY · 2018 to 2022
$788kNCI NIH HHS R01 CA161373NHLBI NIH HHS K01 HL140271NIAID NIH HHS P30 AI045008NIAID NIH HHS UM1 AI126620NIDA NIH HHS R01 DA041765NIDA NIH HHS T32 DA007135NIDDK NIH HHS R01 DK110352NIDDK NIH HHS R01 DK112296NIDDK NIH HHS R01 DK113136NIGMS NIH HHS P20 GM113134NIH HHS S10 OD023547NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD007601
Abstract
Gut homing CD4
Indexed as
AdultAntibodies, Monoclonal, HumanizedB-LymphocytesCD4-Positive T-LymphocytesFemaleGastrointestinal TractHIV InfectionsHumansIntegrinsKiller Cells, NaturalLymphocyte SubsetsLymphoid TissueMaleMiddle AgedRNA, MessengerRNA SplicingAntibodies, Monoclonal, Humanizedintegrin alpha4beta7IntegrinsRNA, Messengervedolizumab
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05186623ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.